TBAF-Catalyzed Cyclization Reactions of o-(Alkynyl)phenyl Propargyl Alcohols with Malonate Esters: A Possible Cation-pi Interaction as The Activation Approach

NWIPB OpenIR

	TBAF-Catalyzed Cyclization Reactions of o-(Alkynyl)phenyl Propargyl Alcohols with Malonate Esters: A Possible Cation-pi Interaction as The Activation Approach
	Zhao, Yulei; Guo, Xuqiang; Wang, Zongkang; Shen, Duyi; Chen, Tingting; Wu, Nan; Yan, Shina; You, Jinmao
	2020
发表期刊	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷号	2020 期号:8
摘要	An efficient method has been devised for the synthesis of dihydroisobenzofuran derivatives through the reaction of in situ generated ynones with potentially C-nucleophilic malonate esters. All the products are capable to be prepared by applying the tandem strategy at room temperature. The reaction was realized through a combination of the pivotal TBAF-catalyzed conjugate addition and selective O-nucleophilic cyclization. As revealed by the control experiments, both the basicity of fluoride anion and ammonium cation-pi interaction with alkyne unit might play crucial roles in the cyclization reaction.
关键词	TBAF Cation-pi interaction Dihydroisobenzofuran Malonate ester Cyclization reaction
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60409
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhao, Yulei,Guo, Xuqiang,Wang, Zongkang,et al. TBAF-Catalyzed Cyclization Reactions of o-(Alkynyl)phenyl Propargyl Alcohols with Malonate Esters: A Possible Cation-pi Interaction as The Activation Approach[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2020,2020(8).
APA	Zhao, Yulei.,Guo, Xuqiang.,Wang, Zongkang.,Shen, Duyi.,Chen, Tingting.,...&You, Jinmao.(2020).TBAF-Catalyzed Cyclization Reactions of o-(Alkynyl)phenyl Propargyl Alcohols with Malonate Esters: A Possible Cation-pi Interaction as The Activation Approach.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2020(8).
MLA	Zhao, Yulei,et al."TBAF-Catalyzed Cyclization Reactions of o-(Alkynyl)phenyl Propargyl Alcohols with Malonate Esters: A Possible Cation-pi Interaction as The Activation Approach".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2020.8(2020).