Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Aspirin Causes Lipid Accumulation and Damage to Cell Membrane by Regulating DCI1/OLE1 in Saccharomyces cerevisiae | |
Zhu, Pan; Li, Ming; Yan, Chongjia; Sun, Jing; Peng, Min; Huang, Zhiwei; Shi, Ping | |
2020 | |
发表期刊 | MICROBIAL DRUG RESISTANCE |
卷号 | 26期号:8 |
摘要 | Aspirin is one of the most commonly used nonsteroidal anti-inflammatory drugs. Various potential pharmacological effects of aspirin, such as anticancer, antibacterial activity, and prolonging life expectancy have been discovered. However, the mechanism of aspirin is not fully elucidated. Herein, the effects of aspirin on fatty acid metabolism in yeast cell model Saccharomyces cerevisiae were studied. The results showed that aspirin can induce lipid accumulation and reduce the unsaturated fat index in cells. The assessment of cell membrane integrity demonstrated that aspirin caused damage to the cell membrane. These effects of aspirin were attributed to the alterations of the expression of DCI1 and OLE1. Similarly, aspirin was able to cause lipid accumulation and damage to the cell membrane by interfering with the expression of OLE1 in Candida albicans. These findings are expected to improve current understanding of the mode of action of aspirin and provide a novel strategy for antifungal drug design. [GRAPHICS] . |
关键词 | aspirin Saccharomyces cerevisiae fatty acid metabolism OLE1 DCI1 |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/60412 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Zhu, Pan,Li, Ming,Yan, Chongjia,et al. Aspirin Causes Lipid Accumulation and Damage to Cell Membrane by Regulating DCI1/OLE1 in Saccharomyces cerevisiae[J]. MICROBIAL DRUG RESISTANCE,2020,26(8). |
APA | Zhu, Pan.,Li, Ming.,Yan, Chongjia.,Sun, Jing.,Peng, Min.,...&Shi, Ping.(2020).Aspirin Causes Lipid Accumulation and Damage to Cell Membrane by Regulating DCI1/OLE1 in Saccharomyces cerevisiae.MICROBIAL DRUG RESISTANCE,26(8). |
MLA | Zhu, Pan,et al."Aspirin Causes Lipid Accumulation and Damage to Cell Membrane by Regulating DCI1/OLE1 in Saccharomyces cerevisiae".MICROBIAL DRUG RESISTANCE 26.8(2020). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论