Neurotoxicity of beta-HgS differs from environmental mercury pollutants (MeHgCl and HgCl2) in Neuro-2a cell

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	Neurotoxicity of beta-HgS differs from environmental mercury pollutants (MeHgCl and HgCl2) in Neuro-2a cell
	Xia, Zhenghua; Bi, Hongtao; Li, Cen; Geng, Lujing; Usman, Muhammad; Du, Yuzhi; Wei, Lixin
	2019
发表期刊	INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
摘要	beta-HgS, differing from environmental mercury pollutants (MeHgCl and HgCl2) in chemical form, is used as traditional medicine in Asian countries for thousands of years. In this study, Neuro-2a cells were exposed to beta-HgS, MeHgCl and HgCl2 (5 mu M) for 6-24 h. The cell viability of beta-HgS was higher than MeHgCl with 25.9% and 72.4% in 12 h and 24 h respectively. As the incubation time increased, MeHgCl had obvious damage to cell morphology, decreased the ratio of Bcl-2 and Bak and increased the expressions of TNF-alpha, IL-6 and IL-1 beta significantly. Furthermore, the expressions of IL-1 beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.
关键词	Beta-HgS MeHgCl HgCl2 neurotoxiciry Neuro-2a
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60480
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Xia, Zhenghua,Bi, Hongtao,Li, Cen,et al. Neurotoxicity of beta-HgS differs from environmental mercury pollutants (MeHgCl and HgCl2) in Neuro-2a cell[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH,2019.
APA	Xia, Zhenghua.,Bi, Hongtao.,Li, Cen.,Geng, Lujing.,Usman, Muhammad.,...&Wei, Lixin.(2019).Neurotoxicity of beta-HgS differs from environmental mercury pollutants (MeHgCl and HgCl2) in Neuro-2a cell.INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH.
MLA	Xia, Zhenghua,et al."Neurotoxicity of beta-HgS differs from environmental mercury pollutants (MeHgCl and HgCl2) in Neuro-2a cell".INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2019).