Elevation is Associated with Human Skin Microbiomes

NWIPB OpenIR

	Elevation is Associated with Human Skin Microbiomes
	Li, Huan; Wang, Yijie; Yu, Qiaoling; Feng, Tianshu; Zhou, Rui; Shao, Liye; Qu, Jiapeng; Li, Nan; Bo, Tingbei; Zhou, Huakun
	2019
发表期刊	MICROORGANISMS
卷号	7 期号:12
摘要	Human skin microbiota plays a crucial role in the defense against pathogens, and is associated with various skin diseases. High elevation is positively correlated with various extreme environmental conditions (i.e., high ultraviolet radiation), which may exert selection pressure on skin microbiota, and therefore influence human health. Most studies regarding skin microbial communities have focused on low-elevation hosts. Few studies have explored skin microbiota in high-elevation humans. Here, we investigated the diversity, function, assembly, and co-occurrence patterns of skin microbiotas from 35 health human subjects across three body sites (forehead, opisthenar, and palm) and seven elevation gradients from 501 to 3431 m. Alpha diversity values (i.e., Shannon diversity and observed operational taxonomic units (OTUs)) decreased with increasing elevation regardless of the body site, while beta diversity (Jaccard and Bray-Curtis dissimilarities) showed an increasing trend with elevation. Elevation is a significant factor that influences human skin microbiota, even after controlling host-related factors. Skin microbiotas at high elevation with more than 3000 m on the Qinghai-Tibet Plateau, had a significant structural or functional separation from those at low elevation with less than 3000 m. Notably, the clustering coefficient, average degree, and network density were all lower at high-elevation than those at low-elevation, suggesting that high-elevation skin networks were more fragile and less connected. Phylogenetic analysis showed that human skin microbiotas are mainly dominated by stochastic processes (58.4%-74.6%), but skin microbiotas at high-elevation harbor a greater portion of deterministic processes than those at low-elevation, indicating that high-elevation may be conducive to the promotion of deterministic processes. Our results reveal that the filtering and selection of the changeable high-elevation environment on the Qinghai-Tibet Plateau may lead to less stable skin microbial community structures.
关键词	Skin microbiome elevation diversity network deterministic processe
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60484
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Li, Huan,Wang, Yijie,Yu, Qiaoling,et al. Elevation is Associated with Human Skin Microbiomes[J]. MICROORGANISMS,2019,7(12).
APA	Li, Huan.,Wang, Yijie.,Yu, Qiaoling.,Feng, Tianshu.,Zhou, Rui.,...&Zhou, Huakun.(2019).Elevation is Associated with Human Skin Microbiomes.MICROORGANISMS,7(12).
MLA	Li, Huan,et al."Elevation is Associated with Human Skin Microbiomes".MICROORGANISMS 7.12(2019).