Integrative analysis of APOL3 gene CNV for adult cattle stature

NWIPB OpenIR

	Integrative analysis of APOL3 gene CNV for adult cattle stature
	Peng, Shu-Jun; Cao, Xiu-Kai; Dong, Dong; Liu, Mei; Hao, Dan; Shen, Xue-Mei; Huang, Yong-Zhen; Lei, Chu-Zhao; Ma, Yun; Bai, Yue-Yu; Hu, Lin-Yong; Qi, Xing-Lei; Chaogetu, Buren; Chen, Hong
	2019
发表期刊	ANIMAL BIOTECHNOLOGY
卷号	31 期号:5
摘要	Copy number variations (CNVs) have been identified as another important structural variation of genome. In recent years, a large amount of CNVRs have been identified in humans and animals. However, association and dosage effects studies of CNVs are very limited. Apolipoprotein L3 (APOL3) gene plays a central role in modulating gene transcription and is located within a CNVR that encompasses quantitative trait locis (QTLs) for economic traits like meat quality. Herein, we analyzed the CNV polymorphism of APOL3 in 421 individuals from five distinct cattle breeds, and then correlated their genotypes with growth traits. Association analysis revealed that the APOL3 CNV was significantly associated with hip height and cannon circumference of Xianan (XN) cattle (P < .01), and visibly associated with body slanting length and hucklebone width of Pinan (PN) cattle (P < .05). Overall, the data provide evidence for the functional role of APOL3 CNV and a basis for future applications in cattle breeding.
关键词	APOL3 CNV cattle stature animal breeding
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60518
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Peng, Shu-Jun,Cao, Xiu-Kai,Dong, Dong,et al. Integrative analysis of APOL3 gene CNV for adult cattle stature[J]. ANIMAL BIOTECHNOLOGY,2019,31(5).
APA	Peng, Shu-Jun.,Cao, Xiu-Kai.,Dong, Dong.,Liu, Mei.,Hao, Dan.,...&Chen, Hong.(2019).Integrative analysis of APOL3 gene CNV for adult cattle stature.ANIMAL BIOTECHNOLOGY,31(5).
MLA	Peng, Shu-Jun,et al."Integrative analysis of APOL3 gene CNV for adult cattle stature".ANIMAL BIOTECHNOLOGY 31.5(2019).