Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia

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	Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia
	Rong, Lin; Li, Guoqiang; Zhang, Yuxia; Xiao, Yuancan; Qiao, Yajun; Yang, Mengmeng; Wei, Lixin; Bi, Hongtao; Gao, Tingting
	2021
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号	189
摘要	Hirsutella sinensis, the anamorph of Ophiocordyceps sinensis (syn. Cordyceps sinensis), is a great substitute for precious and rare wild Cordyceps sinensis to effectively treat a variety of lung and kidney diseases. In this study, an alpha-glucan (named as HSWP-2a) was obtained by hot water extraction, DEAE-cellulose separation, and Sepharose CL-6B purification from H. sinensis mycelia. Different from known alpha-glucans, HSWP-2a is an alpha-(1 -> 4)-D-glucan that branched at O-6, O-3, or O-2 with a terminal 1-linked alpha-D-Glcp as side chain, with an average molecular weight of 870.70 kDa. Immunological tests showed that HSWP-2a could remarkably enhance the phagocytosis of macrophages and increase the production of NO, IL-113, IL-6, and TNF-alpha, via activating the p38, JNK, and NF-KB signaling pathways. Moreover, HSWP-2a could significantly promote splenic lymphocyte proliferation. Taken together, HSWP-2a may be potentially utilized as a natural immunomodulatory agent.
关键词	Hirsutella sinensis alpha-Glucan Structure Immunomodulatory activity
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60684
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Rong, Lin,Li, Guoqiang,Zhang, Yuxia,et al. Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,189.
APA	Rong, Lin.,Li, Guoqiang.,Zhang, Yuxia.,Xiao, Yuancan.,Qiao, Yajun.,...&Gao, Tingting.(2021).Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,189.
MLA	Rong, Lin,et al."Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 189(2021).