Metal-free electrochemical synthesis of alpha-ketoamides via decarboxylative coupling of alpha-keto acids with isocyanides and water

NWIPB OpenIR

	Metal-free electrochemical synthesis of alpha-ketoamides via decarboxylative coupling of alpha-keto acids with isocyanides and water
	Zhao, Feng; Meng, Na; Sun, Ting; Wen, Jiangwei; Zhao, Xiaohui; Wei, Wei
	2021
发表期刊	ORGANIC CHEMISTRY FRONTIERS
摘要	A mild and environmentally benign electrochemical strategy has been developed for the synthesis of alpha-ketoamides via a decarboxylative coupling reaction of alpha-keto acids with isocyanides and water. The present reaction was efficiently conducted under constant current electrolysis using n-Bu4NI as the electrolyte in an undivided cell. A series of alpha-ketoamides could be conveniently and rapidly constructed at room temperature in the absence of transition metal catalysts and external oxidants. Mechanistic studies suggested that water not only served as a starting material to construct alpha-ketoamides, but also played an important role in promoting the electrochemical redox of alpha-keto acids.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60688
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhao, Feng,Meng, Na,Sun, Ting,et al. Metal-free electrochemical synthesis of alpha-ketoamides via decarboxylative coupling of alpha-keto acids with isocyanides and water[J]. ORGANIC CHEMISTRY FRONTIERS,2021.
APA	Zhao, Feng,Meng, Na,Sun, Ting,Wen, Jiangwei,Zhao, Xiaohui,&Wei, Wei.(2021).Metal-free electrochemical synthesis of alpha-ketoamides via decarboxylative coupling of alpha-keto acids with isocyanides and water.ORGANIC CHEMISTRY FRONTIERS.
MLA	Zhao, Feng,et al."Metal-free electrochemical synthesis of alpha-ketoamides via decarboxylative coupling of alpha-keto acids with isocyanides and water".ORGANIC CHEMISTRY FRONTIERS (2021).