Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities

NWIPB OpenIR

	Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities
	Wei, Yangfei; Chen, Tao; Wang, Shuo; Shen, Cheng; Yan, Shuping; Song, Zhibo; Liu, Yarong; Yang, Fengmei; Hai, Ping; Li, Yulin
	2021
发表期刊	NATURAL PRODUCT RESEARCH
摘要	A new triterpenoid saponin, 3-O-beta-D-allopyranosyl (1 -> 3)-alpha-L-rhamnopyranosyl (1 -> 2)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1 -> 4)-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl ester (IV), together with six known ones Hederacholichiside F (I), Tanguticoside B (II), Tauroside St-H-1 (III), Hederoside H-1 (V), Kalopanaxsaponin G (VI), Hederasaponin B (VII) were separated from Clematis tangutica (Maxim.) Korsh. Their cytotoxic activities were evaluated. Saponins IV (new compound) and I showed selective inhibitory activities against HGC-27 with IC50 values of 20.17 and 66.18 mu M. Saponin VII exhibited extensive inhibitory action against HGC-27, Hela and SK-OV-3 with IC50 values of 16.47-71.36 mu M. Saponin III showed selective inhibitory activity against SK-OV-3 with the IC50 value of 48.70 mu M. All isolated saponins were inactive (IC50 >150 mu M) to GES-1.
关键词	Clematis tangutica (Maxim ) Korsh triterpenoid saponins new compound high-speed counter-current chromatography cytotoxic activities
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60711
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wei, Yangfei,Chen, Tao,Wang, Shuo,et al. Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities[J]. NATURAL PRODUCT RESEARCH,2021.
APA	Wei, Yangfei.,Chen, Tao.,Wang, Shuo.,Shen, Cheng.,Yan, Shuping.,...&Li, Yulin.(2021).Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities.NATURAL PRODUCT RESEARCH.
MLA	Wei, Yangfei,et al."Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities".NATURAL PRODUCT RESEARCH (2021).