NWIPB OpenIR
Identification of alpha-glucosidase inhibitors from the bran of Chenopodium quinoa Willd. by surface plasmon resonance coupled with ultra-performance liquid chromatography and quadrupole-time-of-flight-mass spectrometry
Dong, Qi; Hu, Na; Yue, Huilan; Wang, Honglun; Ku, Jinliang
2021
发表期刊JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
卷号1181
摘要Extracts from the bran of Chenopodium quinoa Willd. (QBE) were reported to be active in inhibiting alpha-glycosidase, a promising target for treatment of diabetes mellitus. However, the constituents responsible for the alpha-glucosidase-inhibiting activity of QBE have not been fully characterized. The present study aimed to set up a method for rapid identification of glycosidase inhibiting compounds from the quinoa bran. With surface plasmon resonance (SPR) coupled with liquid chromatography-mass spectrometry (LC-MS), we identified eight flavonoids and ten triterpenoid saponins that may bind to the alpha-glycosidase. Analysis of the interaction kinetics by molecular docking supported their alpha-glucosidase-inhibiting activity and revealed the potential mechanisms for the inhibitory effects. In summary, this study established a SPR and LC-MS-based method for rapid in vitro screening of alpha-glucosidase inhibitors and suggested the quinoa bran a potential natural source of alpha-glucosidase inhibitors.
关键词Chenopodium quinoa Willd alpha-glucosidase inhibitors Surface plasmon resonance Liquid chromatography-mass spectrometry Molecular docking analysis
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/60725
专题中国科学院西北高原生物研究所
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Dong, Qi,Hu, Na,Yue, Huilan,et al. Identification of alpha-glucosidase inhibitors from the bran of Chenopodium quinoa Willd. by surface plasmon resonance coupled with ultra-performance liquid chromatography and quadrupole-time-of-flight-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2021,1181.
APA Dong, Qi,Hu, Na,Yue, Huilan,Wang, Honglun,&Ku, Jinliang.(2021).Identification of alpha-glucosidase inhibitors from the bran of Chenopodium quinoa Willd. by surface plasmon resonance coupled with ultra-performance liquid chromatography and quadrupole-time-of-flight-mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1181.
MLA Dong, Qi,et al."Identification of alpha-glucosidase inhibitors from the bran of Chenopodium quinoa Willd. by surface plasmon resonance coupled with ultra-performance liquid chromatography and quadrupole-time-of-flight-mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1181(2021).
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