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Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury
Meng, Jing; Deng, Kai; Hu, Na; Wang, Honglun
2021
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号186
摘要Nitraria tangutorum Bobr. is suggested to be active in immunoregulation and antioxidation. However, the in vivo bioactivity of N. tangutorum Bobr.-derived polysaccharides (NTP) and their anti-inflammatory activity have not been addressed. In the present study, we extracted and purified polysaccharides from N. tangutorum Bobr. and determined their anti-inflammatory activities in vivo. HPGPC, UHPLC/DAD, and NMR analyses identified that the monosaccharide components of NTP were Man, Rha, GalUA, Glu, Gal, and Ara, with relative contents of 3.52%, 15.08%, 10.00%, 26.73%, 38.08%, and 6.59%, respectively. In mice with lipopolysaccharide (LPS)-induced Acute Lung Injury (ALI), NTP treatment attenuated tissue damage, inhibited the production of inflammatory cytokines, and promoted the anti-oxidative response. The supposed mechanism may be via suppressing the Toll -like receptor 4 (TLR4) signaling pathway. In conclusion, our study suggests a protective role of NTP in LPS-induced ALI by inhibiting inflammatory damage.
关键词Acute lung injury Anti-inflammation Nitraria tangutorum Bobr -derived poly-saccharides
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/60732
专题中国科学院西北高原生物研究所
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GB/T 7714
Meng, Jing,Deng, Kai,Hu, Na,et al. Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,186.
APA Meng, Jing,Deng, Kai,Hu, Na,&Wang, Honglun.(2021).Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,186.
MLA Meng, Jing,et al."Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 186(2021).
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