Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery

NWIPB OpenIR

	Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery
	Peng, Jingyi; Zhang, Lei; Gong, Peiwei; Xu, Wenyu; Qi, Changmin; Yu, Congmin; Liu, Xicheng; Shen, Duyi; Liu, Zhe; You, Jinmao
	2021
发表期刊	JOURNAL OF MOLECULAR LIQUIDS
卷号	337
摘要	Inspired by the structure of leaves that possesses hollow veins and mesophyll with high surface area, a novel MnO2-based biomimetic fluorescence-switchable nanosystem was constructed to visually monitor drug loading and deliver mixed drugs. Leaf-like MnO2 with hollow tubes and wrinkled sheets was first synthesized, and further modified by dopamine for effective loading both hydrophilic and hydrophobic drugs. The degradation of MnO2 can be well controlled by adjusting the thickness of polydopamine film, and the strong pi-pi interactions between them also establish a strong fluorescence resonance energy transfer system, which allows us unprecedentedly to conveniently monitor drug loading process under naked eyes just by judging solution color changes. Additionally, in vitro experimental results demonstrate that the co-drug loaded system exhibits outstanding cancer therapy effect than single therapy, and we also report its first experimental example for effectively anti-cancer migration. The novel biomimetic synthesis method, effective co-loading different drugs with a visual pattern, and much better anticancer and anti-migration effect make our work potentially valuable in many fields. (C) 2021 Elsevier B.V. All rights reserved.
关键词	Fluorescent switches Surface modification Visual loading Drug delivery
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60733
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Peng, Jingyi,Zhang, Lei,Gong, Peiwei,et al. Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery[J]. JOURNAL OF MOLECULAR LIQUIDS,2021,337.
APA	Peng, Jingyi.,Zhang, Lei.,Gong, Peiwei.,Xu, Wenyu.,Qi, Changmin.,...&You, Jinmao.(2021).Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery.JOURNAL OF MOLECULAR LIQUIDS,337.
MLA	Peng, Jingyi,et al."Leaf-inspired fluorescence-switchable nanosystem for visual loading of mixed drugs and targeted delivery".JOURNAL OF MOLECULAR LIQUIDS 337(2021).