The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)

NWIPB OpenIR

	The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)
	Ren, Shien; Fan, Chao; Zhang, Liangzhi; Tang, Xianjiang; Fu, Haibo; Liu, Chuanfa; Jia, Shangang; Zhang, Yanming
	2021
发表期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷号	105 期号:16-17
摘要	Plants produce various plant secondary compounds (PSCs) to deter the foraging of herbivorous mammals. However, little is known about whether PSCs can reshape gut microbiota and promote gut homeostasis of hosts. Using 16S rDNA sequencing to investigate the effects of PSCs on the gut microbiota of small herbivorous mammals, we studied plateau pikas (Ochotona curzoniae) fed diets containing swainsonine (SW) extracted from Oxytropis ochrocephala. Our results showed that both long- and short-term treatment of a single artificial diet in the laboratory significantly reduced alpha diversity and significantly affected beta diversity, core bacteria abundance, and bacterial functions in pikas. After SW was added to the artificial diet, the alpha diversity significantly increased in the long-term treatment, and core bacteria (e.g., Akkermansiaceae) with altered relative abundances in the two treatments showed no significant difference compared with pikas in the wild. The complexity of the co-occurrence network structure was reduced in the artificial diet, but it increased after SW was added in both treatments. Further, the abundances of bacteria related to altered alanine, aspartate, and glutamate metabolism in the artificial diet were restored in response to SW. SW further decreased the concentration of short-chain fatty acids (SCFAs) in both treatments. Our results suggest that PSCs play a key role in regulating gut microbiota community and intestinal homeostasis, thereby maintaining host health.
关键词	Gut microbiota 16S rDNA Plant secondary compounds Swainsonine Plateau pika (Ochotona curzoniae)
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60740
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Ren, Shien,Fan, Chao,Zhang, Liangzhi,et al. The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2021,105(16-17).
APA	Ren, Shien.,Fan, Chao.,Zhang, Liangzhi.,Tang, Xianjiang.,Fu, Haibo.,...&Zhang, Yanming.(2021).The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae).APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,105(16-17).
MLA	Ren, Shien,et al."The plant secondary compound swainsonine reshapes gut microbiota in plateau pikas (Ochotona curzoniae)".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 105.16-17(2021).