Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats

NWIPB OpenIR

	Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats
	Wang, Weien; Zhang, Xiaofeng
	2021
发表期刊	MOLECULES
卷号	26 期号:16
摘要	The aerial part of Biebersteinia heterostemon Maxim. (Geraniaceae Biebersteiniaceae) known as ming jian na bao in Chinese, has been traditionally used in Tibetan folk medicine for treatment of diabetes and hypertension. The aim of the present study was to evaluate the effects of galegine obtained from an ethanol extract of the entire Biebersteinia heterostemon plant on the rat's cardiovascular system in order to characterize its contributions as an antihypertensive agent. The antihypertensive effect of galegine was investigated in pentobarbital-anesthetized hypertensive rats at three dose levels based on the LD50 of galegine. Meanwhile a positive control group received dimaprit with the same procedure. Dimaprit infusion induced a significant hypotension which declined by an average margin of 20%. Simultaneously, single administration of galegine at the doses of 2.5, 5, and 10 mg/kg by intraperitoneal injection induced an immediate and dose-dependent decrease in mean arterial blood pressure (MABP) by an average margin of 40% with a rapid increase in heart rate (HR). We demonstrated that galegine is effective in reducing blood pressure in anesthetized hypertensive rats with rapid onset and a dose-related duration of the effects. The results indicate that galegine was the bioactive compound which can be used as a pharmacophore to design new hypertensive agents.
关键词	Biebersteinia heterostemon galegine hypotensive toxicity
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60755
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, Weien,Zhang, Xiaofeng. Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats[J]. MOLECULES,2021,26(16).
APA	Wang, Weien,&Zhang, Xiaofeng.(2021).Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats.MOLECULES,26(16).
MLA	Wang, Weien,et al."Antihypertensive Effect of Galegine from Biebersteinia heterostemon in Rats".MOLECULES 26.16(2021).