Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response

NWIPB OpenIR

	Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response
	Wang, Hailiang; Zhou, Jianhong; Bi, Hongtao; Yang, Xiaoyu; Chen, Wenlong; Jiang, Kuijun; Yao, Yang; Ni, Weihua
	2021
发表期刊	JOURNAL OF MEDICINAL FOOD
卷号	24 期号:7
摘要	Nitraria tangutorun Bobr. has been used for thousands of years as a native folk medicine to alleviate dizziness and neurasthenia due to oxygen. In our previous study, natural antioxidant components (namely, NJBE) were isolated from industrial N. tangutorun Bobr. juice byproducts (NJBE) from the Qinghai-Tibet plateau. The current investigation assessed the effects of NJBE on ischemic stroke in mice and the potential mechanisms. C57BL/6 mice received NJBE (25, 50, or 100 mg/Kg) by gavage for 14 days and then stroke was induced by the middle cerebral artery occlusion (MCAO) model, followed by reperfusion for 72 h. The evaluation of brain infarct size, behavioral tests, and functional assessments was conducted to assess the effects of NJBE after MCAO. Our results suggested that NJBE significantly decreases infarct size, improves neurological deficits, as well as reduces the number of GFAP(+) and Iba-1(+) cells after MCAO. NJBE inhibited nitric oxide and malondialdehyde production in the ischemic brain. Meanwhile, it attenuated the expressions of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Also, NJBE significantly attenuated the expression levels of proinflammatory indicators, including TNF-alpha, IL-1 beta, IL-6, and IL-12. This process was accompanied by the downregulation of TLR4, TRAF6, pI kappa B/pI kappa B, and MMP9 expression and the upregulation of claudin-5 expression. NJBE induced improvements in brain injury. The neuroprotective effect of NJBE provides evidence for its potential application in stroke treatment.
关键词	anti-inflammatory blood-brain barrier focal cerebral ischemia neuroprotection Nitraria tangutorun Bobr oxidative stress
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60779
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, Hailiang,Zhou, Jianhong,Bi, Hongtao,et al. Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response[J]. JOURNAL OF MEDICINAL FOOD,2021,24(7).
APA	Wang, Hailiang.,Zhou, Jianhong.,Bi, Hongtao.,Yang, Xiaoyu.,Chen, Wenlong.,...&Ni, Weihua.(2021).Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response.JOURNAL OF MEDICINAL FOOD,24(7).
MLA	Wang, Hailiang,et al."Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response".JOURNAL OF MEDICINAL FOOD 24.7(2021).