NWIPB OpenIR
Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment
Li, Min; Lan, Xi; Han, Ximei; Shi, Shuo; Sun, Hao; Kang, Yi; Dan, Jie; Sun, Jing; Zhang, Wentao; Wang, Jianlong
2021
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号13期号:25
摘要Nanoantibacterial agents based on catalytic activity were limited due to the low levels of endogenous H2O2 in the microenvironment of bacterial biofilms. However, the additional H2O2 will trigger more side effects to healthy surroundings, which is still a great challenge. Herein, we report an acid-induced self-catalyzing platform based on dextran-coated copper peroxide nanoaggregates (DCPNAs) for antibiofilm and local infection therapy applications. The dextran-functionalized DCPNAs were mediated and conveniently purified via a dextran and ethanol precipitation method, which can also cluster nanodots into nanoaggregates and show good penetrability as well as biocompatibility. Bacterial biofilms were inhibited and destroyed by the reactive oxygen species generated from the Fenton reaction between the Cu2+ and H2O2 released from DCPNAs in an acidic environment, which did not require additional H2O2. As expected, the DCPNAs exhibit low cytotoxicity and excellent acid-induced antibacterial and antibiofilm ability. Moreover, the DCPNAs realized great therapeutic outcomes in the application for in vivo wound healing. The overall excellent properties associated with the DCPNAs highlight that they could be considered as a kind of ideal antimicrobial agents for microbial biofilm infection treatment.
关键词self-catalyzing antibiofilm dextran nanoaggregates wound healing
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/60781
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Li, Min,Lan, Xi,Han, Ximei,et al. Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(25).
APA Li, Min.,Lan, Xi.,Han, Ximei.,Shi, Shuo.,Sun, Hao.,...&Wang, Jianlong.(2021).Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment.ACS APPLIED MATERIALS & INTERFACES,13(25).
MLA Li, Min,et al."Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment".ACS APPLIED MATERIALS & INTERFACES 13.25(2021).
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