Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

NWIPB OpenIR

	Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis
	Liu, Wenjing; Peng, Lei; Tian, Wanli; Li, Yi; Zhang, Ping; Sun, Kuanxiang; Yang, Yeming; Li, Xiao; Li, Guisen; Zhu, Xianjun
	2021
发表期刊	DISEASE MODELS & MECHANISMS
卷号	14 期号:6
摘要	The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the 0-subunit TMEM30A. Podocytes in the glomerulus form a filtration barrier to prevent the traversing of large cellular elements and macromolecules from the blood into the urinary space. Damage to podocytes can disrupt the filtration barrier and lead to proteinuria and podocytopathy. We observed reduced TMEM30A expression in patients with minimal change disease and membranous nephropathy, indicating potential roles of TMEM30A in podocytopathy. To investigate the role of Tmem30a in the kidney, we generated a podocyte-specific Tmem30a knockout (KO) mouse model using the NPHS2-Cre line. Tmem30a KO mice displayed albuminuria, podocyte degeneration, mesangial cell proliferation with prominent extracellular matrix accumulation and eventual progression to focal segmental glomerulosclerosis. Our data demonstrate a critical role of Tmem30a in maintaining podocyte survival and glomerular filtration barrier integrity. Understanding the dynamic regulation of the PS distribution in the glomerulus provides a unique perspective to pinpointing the mechanism of podocyte damage and potential therapeutic targets.
关键词	Tmem30a Albuminuria Focal segmental glomerulosclerosis Glomerulosclerosis
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60795
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Liu, Wenjing,Peng, Lei,Tian, Wanli,et al. Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis[J]. DISEASE MODELS & MECHANISMS,2021,14(6).
APA	Liu, Wenjing.,Peng, Lei.,Tian, Wanli.,Li, Yi.,Zhang, Ping.,...&Zhu, Xianjun.(2021).Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis.DISEASE MODELS & MECHANISMS,14(6).
MLA	Liu, Wenjing,et al."Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis".DISEASE MODELS & MECHANISMS 14.6(2021).