Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo

NWIPB OpenIR

	Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo
	Jiang, Sirong; Zhao, Xiaohui; Liu, Chuang; Dong, Qi; Mei, Lijuan; Chen, Chen; Shao, Yun; Tao, Yanduo; Yue, Huilan
	2021
发表期刊	FOOD CHEMISTRY
卷号	344
摘要	The gooseberry (Ribes stenocarpum Maxim. (CBZ)) is a wild and noncommercially cultivated berry fruit widely distributed in the Tibetan Plateau. The phenolic constituents from the berry fruit of CBZ were firstly identified by employing UPLC-QTOF MS. A total of 41 compounds, including hydroxycinnamic acids, hydroxybenzoic acids, flavonols and dihydmflavonol, were identified in view of their molecular weight, characteristic fragment ions and retention times. Further in vitro enzyme assay indicated that CBZ fruit extract could strongly and effectively inhibited alpha-glucosidase and alpha-amylase, with the IC(50 )values of 0.013 mg/mL and 0.005 mg/mL, respectively. In addition, the starch/maltose/sucrose tolerance experiment demonstrated that the CBZ fruit extract could reduce the sucrose mediated postprandial blood glucose (PBG) levels in normal mice, and significantly lower starch/ maltose/ sucrose mediated PBG levels in diabetic mice. These results suggested that this berry fruit could be used as a dietary supplement, or drug for the control of hyperglycemia.
关键词	Ribes stenocarpum Maxim. phenolic compounds Postprandial blood glucose alpha-Glucosidase alpha-Amylase
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/60806
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Jiang, Sirong,Zhao, Xiaohui,Liu, Chuang,et al. Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo[J]. FOOD CHEMISTRY,2021,344.
APA	Jiang, Sirong.,Zhao, Xiaohui.,Liu, Chuang.,Dong, Qi.,Mei, Lijuan.,...&Yue, Huilan.(2021).Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo.FOOD CHEMISTRY,344.
MLA	Jiang, Sirong,et al."Identification of phenolic compounds in fruits of Ribes stenocarpum Maxim. By UHPLC-QTOF/MS and their hypoglycemic effects in vitro and in vivo".FOOD CHEMISTRY 344(2021).