Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease | |
Ma, Siyue; Chen, Guang; Xu, Jie; Liu, Yuxia; Li, Guoliang; Chen, Tao; Li, Yulin; James, Tony D. | |
2021 | |
发表期刊 | COORDINATION CHEMISTRY REVIEWS |
卷号 | 427 |
摘要 | One of the most prevalent forms of dementia is Alzheimer's disease (AD) which causes severe memory impairment within humans. As such, research into the early diagnosis of AD is essential to help treatment, which has led to significant advances in fluorescence imaging. Unfortunately, modern medicine and biology place increasingly strict requirements for fluorescent probes. Therefore, over recent years, researchers have taken strides to develop novel fluorescent molecular probes, with properties suitable for modern clinical applications, including low phototoxicity, weak background interference, deep tissue penetration, enhanced specificity, strong binding affinity, and suitable permeability through the blood-brain barrier (BBB). From these recent research results, many novel concepts for molecular design and fluorescence techniques have emerged. Herein, we present strategies towards the development of probes capable of meeting the advanced clinical requirements. As part of this review, we will summarize the characteristic enzymes and proteins involved in AD progression, including Amyloid-beta, beta-secretase, tau protein, monoamine oxidases, and methionine sulfoxide reductase. Then, we will evaluate some of the early probes and summarize the recent advancements made in the design of probes suitable for clinical applications, from which several strategies have emerged, such as increasing permeability to the blood-brain barrier, enhancing specificity by boosting binding affinity, and improving optical properties for in vivo imaging, etc. Then to conclude current strategies for early stage diagnosis of AD will be presented, and the opportunities as well as the remaining challenges will be outlined. (C) 2020 Elsevier B.V. All rights reserved. |
关键词 | Alzheimer's disease Fluorescence imaging Molecular Probes Enzyme Protein |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/60871 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Ma, Siyue,Chen, Guang,Xu, Jie,et al. Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease[J]. COORDINATION CHEMISTRY REVIEWS,2021,427. |
APA | Ma, Siyue.,Chen, Guang.,Xu, Jie.,Liu, Yuxia.,Li, Guoliang.,...&James, Tony D..(2021).Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease.COORDINATION CHEMISTRY REVIEWS,427. |
MLA | Ma, Siyue,et al."Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer's disease".COORDINATION CHEMISTRY REVIEWS 427(2021). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论