Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity

NWIPB OpenIR

	Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity
	Ma, YH; Suo, XY; Li, XX; Zhu, TT; Li, J; Ji, TF; Liu, B
	2022
发表期刊	PHYTOCHEMISTRY
卷号	203
摘要	Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 mu M. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61064
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Ma, YH,Suo, XY,Li, XX,et al. Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity[J]. PHYTOCHEMISTRY,2022,203.
APA	Ma, YH.,Suo, XY.,Li, XX.,Zhu, TT.,Li, J.,...&Liu, B.(2022).Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity.PHYTOCHEMISTRY,203.
MLA	Ma, YH,et al."Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity".PHYTOCHEMISTRY 203(2022).