Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities

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	Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities
	Cao, JY; Dong, Q; Wang, ZY; Zhao, Y; Ren, Y; Liu, C; Dang, J; Yu, RT; Tao, YD
	2022
发表期刊	ARABIAN JOURNAL OF CHEMISTRY
卷号	15 期号:10
摘要	Five new arylnaphthalide lignans (1 -4a/4b), together with five known analogues (5-9), were isolated from whole plants of Saussurea medusa. Compound 4 was characterized as an arylte-tralin lignan with an unusual C-7'-C-9 oxygen bridge group, and a chiral HPLC analysis was carried out to afford one pair of enantiomers (4a/4b). Structures of the new compounds were elucidated by extensive spectroscopic and electronic circular dichroism (ECD) calculations. All compounds were firstly isolated from S. medusa, and compounds 1-5, 7 and 8 had never been obtained from the genus Saussurea previously. Furthermore, this is the first report of arylnaphthalide lignans isolated from S. medusa. anti-inflammatory activities of the compounds were evaluated by determining their inhibitory activities on the production of NO by LPS-stimulated RAW 264.7 cells. Compounds (-)-4a and 5 exerted the significant inhibition activities with IC50 values of 13.4 +/- 1.5 and 15.7 +/- 1. 1 lM, respectively, which even exceeded the positive control quercetin (IC50 = 15.9 +/- 1.2 lM). Compounds 2, (+)-4b, 6 and 9 exhibited moderate inhibitory activities with IC50 values ranging from 19.7 +/- 1.9 to 47.4 +/- 3.1 lM. Further analysis by molecular docking showed that almost all the active compounds could interact with the amino acid residues of iNOS proteins, which also supported their anti-inflammatory activities.(c) 2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61084
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Cao, JY,Dong, Q,Wang, ZY,et al. Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities[J]. ARABIAN JOURNAL OF CHEMISTRY,2022,15(10).
APA	Cao, JY.,Dong, Q.,Wang, ZY.,Zhao, Y.,Ren, Y.,...&Tao, YD.(2022).Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities.ARABIAN JOURNAL OF CHEMISTRY,15(10).
MLA	Cao, JY,et al."Arylnaphthalide lignans from Saussurea medusa and their anti-inflammatory activities".ARABIAN JOURNAL OF CHEMISTRY 15.10(2022).