Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity

NWIPB OpenIR

	Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity
	Chai, JH; Ma, YY; Guo, TL; He, Y; Wang, GS; Si, FF; Geng, JH; Qi, XW; Chang, GQ; Ren, ZG; Yu, RT; Song, LY; Li, D
	2022
发表期刊	APPLIED CLAY SCIENCE
卷号	228
摘要	This article presented a facile two-step hydrothermal strategy to anchor the Fe3O4 nanoparticles on the surface of Zn-Al LDH nanosheets, and investigated systematically the potential application of the constructed Fe3O4/Zn-Al LDH nanocomposites in the biomedical field of controlled drug delivery. It was revealed that the formed Fe3O4/ Zn-Al LDH nanocomposites exhibited uniform mesopores, high surface area of 121.7 m2/g, good superparamagnetism and appropriate saturation magnetization of 40.7 emu/g. Due to these fascinating properties, this work explored the application of Fe3O4/Zn-Al LDH in the field of nanocarrier using the doxorubicin hydrochloride (DOX) as a model anticancer drug for the detailed investigations of drug loading capacity, controlled release behavior and cytotoxic effects under in vitro conditions. The Fe3O4/Zn-Al LDH showed a good drug storage capacity and a pH-responsive drug release profile. After loading the anti-cancer drugs, the DOX-loaded Fe3O4/Zn-Al LDH exhibited enhanced therapeutic effect on human hepatocellular carcinoma cells (HepG2), demonstrating that the fabricated Fe3O4/Zn-Al LDH nanocomposites have a great potential in cancer therapy.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61085
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Chai, JH,Ma, YY,Guo, TL,et al. Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity[J]. APPLIED CLAY SCIENCE,2022,228.
APA	Chai, JH.,Ma, YY.,Guo, TL.,He, Y.,Wang, GS.,...&Li, D.(2022).Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity.APPLIED CLAY SCIENCE,228.
MLA	Chai, JH,et al."Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity".APPLIED CLAY SCIENCE 228(2022).