Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum

NWIPB OpenIR

	Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum
	Luo, T; Deng, XM; Li, Z; Liu, D; Wen, HX; Wang, Z
	2022
发表期刊	PHYTOCHEMISTRY LETTERS
卷号	51 页码:119
摘要	Hypecoum leptocarpum is a traditional Tibetan Medicine, which has been shown to have anti-cancer properties. Therefore, developing anti-cancer activity compounds from Hypecoum leptocarpum is very valuable. Notably, corydamine, an isoquinoline alkaloid, is isolated from Hypecoum leptocarpum. Given the anti-cancer value of Hypecoum leptocarpum, lucubrating the anti-cancer activity of corydamine is of great value in the development of novel anti-cancer drugs. In this study, synthesis and anti-cancer activity evaluation of corydamine were completed. The research in vitro confirmed corydamine suppressed cell proliferation and metastasis, arrested cell cycle at G1/G0 phase, triggered mitochondrial pathway apoptosis through inhibiting the activation of PI3K/AKT/ mTOR pathway. Studies in vivo on LM9 xenograft nude mice demonstrated that corydamine therapy markedly inhibited tumor growth. These findings revealed corydamine might be a candidate for the treatment of hepa-tocellular carcinoma.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61094
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Luo, T,Deng, XM,Li, Z,et al. Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum[J]. PHYTOCHEMISTRY LETTERS,2022,51:119.
APA	Luo, T,Deng, XM,Li, Z,Liu, D,Wen, HX,&Wang, Z.(2022).Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum.PHYTOCHEMISTRY LETTERS,51,119.
MLA	Luo, T,et al."Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum".PHYTOCHEMISTRY LETTERS 51(2022):119.