Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Engineered Core-Shell Multifunctional Nano-Tracer in Raman-Silent Region with Highly Retained Affinity to Enhance Lateral Flow Immunoassays | |
Liu, SJ; Luo, X; Shu, R; Liao, YJ; Dou, LN; Bu, T; Wang, SC; Li, YC; Sun, J; Zhang, DH; Zhu, MQ; Wang, JL | |
2022 | |
发表期刊 | SMALL |
卷号 | 18期号:45 |
摘要 | Stimulated surface-enhanced Raman scattering (SERS) in combination with engineered nano-tracer offers extraordinary potential in lateral flow immunoassays (LFIAs). Nonetheless, the investigation execution of SERS-LFIA is often compromised by the intricacy and overlap of the Raman fingerprint spectrum as well as the affinity-interference of nano-tracer to antibody. To circumvent these critical issues, an engineered core-shell multifunctional nano-tracer (named APNPs) with precise control of the size of nano-core (AuNPs) and coating of the nano-shell (Prussian blue nanomaterials) is prepared for SERS-LFIA via a modified enlarging particle size and coating modification strategy. Importantly, this nano-tracer exhibits enhanced coupling efficiency, highly retained affinity, reinforced colloid stability, and unique SERS signal (2156 cm(-1)) in the silent region (1800-2800 cm(-1)) with high signal-to-background ratio simultaneously, all of which are beneficial to the enhancement of the analysis performance. With a proof-of-concept demonstration for detection of ractopamine (RAC), a dual-pattern LFIA that synergizes both the enlarged particle size and coating modification supported colorimetric/biological silence Raman dual-response (coined as the ECCRD assay) is demonstrated by integrating APNPs with the competitive-type immunoreaction. This research may contribute to the rational design of multifunctional nano-tracer, and the ECCRD assay can be expanded for a wide spectrum of applications in environmental monitoring and biomedical diagnosis. |
收录类别 | SCIE |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/61102 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Liu, SJ,Luo, X,Shu, R,et al. Engineered Core-Shell Multifunctional Nano-Tracer in Raman-Silent Region with Highly Retained Affinity to Enhance Lateral Flow Immunoassays[J]. SMALL,2022,18(45). |
APA | Liu, SJ.,Luo, X.,Shu, R.,Liao, YJ.,Dou, LN.,...&Wang, JL.(2022).Engineered Core-Shell Multifunctional Nano-Tracer in Raman-Silent Region with Highly Retained Affinity to Enhance Lateral Flow Immunoassays.SMALL,18(45). |
MLA | Liu, SJ,et al."Engineered Core-Shell Multifunctional Nano-Tracer in Raman-Silent Region with Highly Retained Affinity to Enhance Lateral Flow Immunoassays".SMALL 18.45(2022). |
条目包含的文件 | 条目无相关文件。 |
个性服务 |
推荐该条目 |
保存到收藏夹 |
查看访问统计 |
导出为Endnote文件 |
谷歌学术 |
谷歌学术中相似的文章 |
[Liu, SJ]的文章 |
[Luo, X]的文章 |
[Shu, R]的文章 |
百度学术 |
百度学术中相似的文章 |
[Liu, SJ]的文章 |
[Luo, X]的文章 |
[Shu, R]的文章 |
必应学术 |
必应学术中相似的文章 |
[Liu, SJ]的文章 |
[Luo, X]的文章 |
[Shu, R]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论