Research on nonlinear quantification of Rebaudioside A crystallization process based on near-infrared sensor fusion

NWIPB OpenIR

	Research on nonlinear quantification of Rebaudioside A crystallization process based on near-infrared sensor fusion
	Dong, HL; Huang, RQ; Gao, LL; Yang, Y; Xu, XH; Nie, L; Li, L; Dong, Q; Zhang, H; Xu, JK; Sun, J; Zang, HC
	2022
发表期刊	JOURNAL OF PHARMACEUTICAL INNOVATION
摘要	Purposes Rebaudioside A (RA) is a natural sweetener whose key manufacturing step is crystallization. However, a rapid detection method suitable for this process is currently absent. With miniaturization becoming a trend in industrial applications, near-infrared (NIR) spectroscopy has become a powerful tool for understanding the manufacturing process of natural products. The potential of miniature NIR for quantification of RA content and visualization of the crystallization process was investigated in this study. Methods The RA crystallization process was simulated in our laboratory. During the crystallization, the NIR spectra were collected using two micro-sensors (1350 similar to 1650 nm and 1550 similar to 1950 nm). To improve the performance of the model, convolution neural network (CNN) with sensor fusion was proposed. Results The CNN model based on raw spectral fusion showed the best predictive capacity with RMSEP and RPD of 2.895 mg/mL and 3.919, respectively. Conclusions Overall, the research showed that the CNN model with data fusion was promising for quantifying and visualizing RA crystallization based on NIR. This study promoted the popularization of portable spectrometers by providing a theoretical basis for instrument customization.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61106
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Dong, HL,Huang, RQ,Gao, LL,et al. Research on nonlinear quantification of Rebaudioside A crystallization process based on near-infrared sensor fusion[J]. JOURNAL OF PHARMACEUTICAL INNOVATION,2022.
APA	Dong, HL.,Huang, RQ.,Gao, LL.,Yang, Y.,Xu, XH.,...&Zang, HC.(2022).Research on nonlinear quantification of Rebaudioside A crystallization process based on near-infrared sensor fusion.JOURNAL OF PHARMACEUTICAL INNOVATION.
MLA	Dong, HL,et al."Research on nonlinear quantification of Rebaudioside A crystallization process based on near-infrared sensor fusion".JOURNAL OF PHARMACEUTICAL INNOVATION (2022).