Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes

NWIPB OpenIR

	Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes
	Wang, HJ; Liu, DX; Song, PF; Jiang, F; Zhang, TZ
	2022
Source Publication	GENES
Volume	13 Issue:7
Abstract	In high-altitude environments, the prevalence of high-altitude polycythemia (HAPC) ranges between 5 and 18 percent. However, there is currently no effective treatment for this condition. Therefore, disease prevention has emerged as a critical strategy against this disease. Here, we looked into the microarray profiles of GSE135109 and GSE29977, linked to either short- or long-term exposure to the Qinghai Tibet Plateau (QTP). The results revealed inhibition in the adaptive immune response during 30 days of exposure to QTP. Following a gene set enrichment analysis (GSEA) discovered that genes associated with HAPC were enriched in Cluster1, which showed a dramatic upregulation on the third day after arriving at the QTP. We then used GeneLogit to construct a logistic prediction model, which allowed us to identify 50 genes that classify HAPC patients. In these genes, LRRC18 and HCAR3 were also significantly altered following early QTP exposure, suggesting that they may serve as hub genes for HAPC development. The in-depth study of a combination of the datasets of transcriptomic changes during exposure to a high altitude and whether diseases occur after long-term exposure in Hans can give us some inspiration about genes associated with HAPC development during adaption to high altitudes.
Indexed By	SCIE
Document Type	期刊论文
Identifier	http://210.75.249.4/handle/363003/61170
Collection	中国科学院西北高原生物研究所
Recommended Citation GB/T 7714	Wang, HJ,Liu, DX,Song, PF,et al. Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes[J]. GENES,2022,13(7).
APA	Wang, HJ,Liu, DX,Song, PF,Jiang, F,&Zhang, TZ.(2022).Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes.GENES,13(7).
MLA	Wang, HJ,et al."Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes".GENES 13.7(2022).

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