NWIPB OpenIR
Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes
Wang, HJ; Liu, DX; Song, PF; Jiang, F; Zhang, TZ
2022
Source PublicationGENES
Volume13Issue:7
AbstractIn high-altitude environments, the prevalence of high-altitude polycythemia (HAPC) ranges between 5 and 18 percent. However, there is currently no effective treatment for this condition. Therefore, disease prevention has emerged as a critical strategy against this disease. Here, we looked into the microarray profiles of GSE135109 and GSE29977, linked to either short- or long-term exposure to the Qinghai Tibet Plateau (QTP). The results revealed inhibition in the adaptive immune response during 30 days of exposure to QTP. Following a gene set enrichment analysis (GSEA) discovered that genes associated with HAPC were enriched in Cluster1, which showed a dramatic upregulation on the third day after arriving at the QTP. We then used GeneLogit to construct a logistic prediction model, which allowed us to identify 50 genes that classify HAPC patients. In these genes, LRRC18 and HCAR3 were also significantly altered following early QTP exposure, suggesting that they may serve as hub genes for HAPC development. The in-depth study of a combination of the datasets of transcriptomic changes during exposure to a high altitude and whether diseases occur after long-term exposure in Hans can give us some inspiration about genes associated with HAPC development during adaption to high altitudes.
Indexed BySCIE
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/61170
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Wang, HJ,Liu, DX,Song, PF,et al. Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes[J]. GENES,2022,13(7).
APA Wang, HJ,Liu, DX,Song, PF,Jiang, F,&Zhang, TZ.(2022).Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes.GENES,13(7).
MLA Wang, HJ,et al."Microarray-Based Prediction of Polycythemia after Exposure to High Altitudes".GENES 13.7(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, HJ]'s Articles
[Liu, DX]'s Articles
[Song, PF]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, HJ]'s Articles
[Liu, DX]'s Articles
[Song, PF]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, HJ]'s Articles
[Liu, DX]'s Articles
[Song, PF]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.