Mitochondrial Calcium Disorder Affects Early Embryonic Development in Mice through Regulating the ERK/MAPK Pathway

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	Mitochondrial Calcium Disorder Affects Early Embryonic Development in Mice through Regulating the ERK/MAPK Pathway
	Zhang, LY; Liu, KX; Zhuan, QR; Liu, ZQ; Meng, L; Fu, XW; Jia, GX; Hou, YP
	2022
发表期刊	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
卷号	2022
摘要	The homeostasis of mitochondrial calcium ([Ca2+](mt)) in oocytes plays a critical role in maintaining normal reproductive cellular progress such as meiosis. However, little is known about the association between [Ca2+](mt) homeostasis and early embryonic development. Two in vitro mouse MII oocyte models were established by using a specific agonist or inhibitor targeting mitochondrial calcium uniporters (MCU) to upregulate or downregulate [Ca2+](mt) concentrations. The imbalance of [Ca2+](mt) in MII oocytes causes mitochondrial dysfunction and morphological abnormity, leading to an abnormal spindle/chromosome structure. Oocytes in drug-treated groups are less likely to develop into blastocyst during in vitro culture. Abnormal [Ca2+](mt) concentrations in oocytes hindered epigenetic modification and regulated mitogen-activated protein kinase (MAPK) signaling that is associated with gene expression. We also found that MAPK/ERK signaling is regulating DNA methylation in MII oocytes to modulate epigenetic modification. These data provide a new insight into the protective role of [Ca2+](mt) homeostasis in early embryonic development and also demonstrate a new mechanism of MAPK signaling regulated by [Ca2+](mt) that influences epigenetic modification.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61210
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, LY,Liu, KX,Zhuan, QR,et al. Mitochondrial Calcium Disorder Affects Early Embryonic Development in Mice through Regulating the ERK/MAPK Pathway[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022,2022.
APA	Zhang, LY.,Liu, KX.,Zhuan, QR.,Liu, ZQ.,Meng, L.,...&Hou, YP.(2022).Mitochondrial Calcium Disorder Affects Early Embryonic Development in Mice through Regulating the ERK/MAPK Pathway.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022.
MLA	Zhang, LY,et al."Mitochondrial Calcium Disorder Affects Early Embryonic Development in Mice through Regulating the ERK/MAPK Pathway".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022(2022).