Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities

NWIPB OpenIR

	Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities
	Yue, HL; Jiang, SR; Wang, LY; Banma, CL; Zhou, GY; Shao, Y; Tao, YD; Zhao, XH
	2022
发表期刊	INDUSTRIAL CROPS AND PRODUCTS
卷号	178
摘要	Rheum tanguticum Maxim. ex Balf. (RT), mainly is mainly produced in Gansu, Qinghai, Tibet and Sichuan of China, has long been used as a medicine for purging fire and quenching thirst. The RTR-2 (Rheum tanguticum root extract without polysaccharides and protein) had strong inhibitory activities against a-amylase, maltase and sucrase with the IC50 0.042 mg/mL, 0.124 mg/mL and 0.097 mg/mL, respectively. In addition, RTR-2 could significantly reduce PBG level of diabetic mice in starch/maltose/sucrose tolerance test. Total 48 constituents including 12 anthraquinones, 4 bianthmnes, 8 flavans, 3 stilbenes, 5 phenylbutanones, 4 naphthosides, 8 glucose gallates and 4 phenolic acids were determined in RTR-2 by UPLC-Triple-TOF/MS analysis of molecular ion, main fragments, retention time, and references. Furthermore, the components such as flavan ((-)-epicatechin 3-O-gallate) and phenylbutanone (lindleyin) were demonstrated to have sucrase and maltase inhibitory activites, and might be the main hypoglycemic active ingredients of RTR-2 extract. All these results offered an exhaustive knowledge for the hypoglycemic compounds of Rheum tanguticum, which was conducive to its further development and utilization as a valuable source of hypoglycemic plant in pharmaceutical industry.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61260
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yue, HL,Jiang, SR,Wang, LY,et al. Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities[J]. INDUSTRIAL CROPS AND PRODUCTS,2022,178.
APA	Yue, HL.,Jiang, SR.,Wang, LY.,Banma, CL.,Zhou, GY.,...&Zhao, XH.(2022).Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities.INDUSTRIAL CROPS AND PRODUCTS,178.
MLA	Yue, HL,et al."Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities".INDUSTRIAL CROPS AND PRODUCTS 178(2022).