NWIPB OpenIR
Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS
Jia, WJ; Bi, QM; Jiang, SR; Tao, JH; Liu, LY; Yue, HL; Zhao, XH
2022
发表期刊FOOD & FUNCTION
卷号13期号:5页码:2456
摘要Codonopsis pilosula (Franch.) Nannf. (CPN), mainly planted in the northwest region, is a traditional Chinese medicine/good health food for nourishing qi and promoting blood circulation. This study firstly evaluated the inhibitory effects of the CPN extraction (CPNE) on alpha-glucosidase in vitro and in vivo, and tentatively confirmed its chemical ingredients by employing UHPLC-Triple-TOF-MS/MS. The CPNE had strong inhibitory activities against mammalian alpha-glucosidase (sucrase and maltase) and yeast alpha-glycosidase with semi-inhibitory concentrations (IC50) of 0.241 mg mL(-1), 0.326 mg mL(-1) and 1.167 mg mL(-1), respectively. In addition, the CPNE could significantly decrease the postprandial blood glucose (PBG) levels in the sucrose/maltose/starch tolerance assays of diabetic mice. Furthermore, a total of 29 compounds, including 3 alkaloids, 13 phenolic acids, 8 alcohol glycosides and 5 alkynosides, were assigned based on comparison with the standards and references, as well as the analysis of main fragments. These results demonstrated that CPN could be used as an adjuvant therapy or dietary supplements to effectively control the occurrence and development of diabetes.
收录类别SCIE
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/61289
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Jia, WJ,Bi, QM,Jiang, SR,et al. Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS[J]. FOOD & FUNCTION,2022,13(5):2456.
APA Jia, WJ.,Bi, QM.,Jiang, SR.,Tao, JH.,Liu, LY.,...&Zhao, XH.(2022).Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS.FOOD & FUNCTION,13(5),2456.
MLA Jia, WJ,et al."Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS".FOOD & FUNCTION 13.5(2022):2456.
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