Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau

NWIPB OpenIR

	Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau
	Kurskaya, O; Prokopyeva, E; Bi, HT; Sobolev, I; Murashkina, T; Shestopalov, A; Wei, LX; Sharshov, K
	2022
发表期刊	VIRUSES-BASEL
卷号	14 期号:2
摘要	To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai-Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 mu g/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6-125 mu g/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61295
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Kurskaya, O,Prokopyeva, E,Bi, HT,et al. Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau[J]. VIRUSES-BASEL,2022,14(2).
APA	Kurskaya, O.,Prokopyeva, E.,Bi, HT.,Sobolev, I.,Murashkina, T.,...&Sharshov, K.(2022).Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau.VIRUSES-BASEL,14(2).
MLA	Kurskaya, O,et al."Anti-Influenza Activity of Medicinal Material Extracts from Qinghai-Tibet Plateau".VIRUSES-BASEL 14.2(2022).