Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds

NWIPB OpenIR

	Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds
	Wang, XG; Wang, YR; Cao, XK; Huang, YZ; Li, P; Lan, XY; Buren, C; Hu, LY; Chen, H
	2021
发表期刊	ANIMAL BIOTECHNOLOGY
摘要	Copy number variation (CNV) is one kind of genomic structure variations and presents as gains and losses of genomic fragments. More recently, we have made an atlas of CNV maps for livestock. In the future, it is a primary focus to determine the phenotypic effects of candidate CNVs. Lysine Acetyltransferase 6 A (KAT6A) is a protein coding gene and plays a critical role in many cellular processes. However, the effects of KAT6A CNVs on sheep body measurements remains unknown. In this study, we performed quantitative polymerase chain reaction (qPCR) to detect the presences and distributions of three CNV regions within KAT6A gene in 672 sheep from four Chinese breeds. Association analysis indicated that the three CNVs of KAT6A gene were significantly associated with body measurement(s) in Small-tailed Han sheep (STH) and Hu sheep (HU) (p < 0.05), while no effects on Large-tailed Han sheep (LTH) were observed (p > 0.05) were observed. Additionally, only one CNV was significantly associated with body measurement (body length) in Chaka sheep (CK) (p < 0.05). Our study provided evidence that the CNV(s) of KAT6A gene could be used as candidate marker(s) for molecular breedings of STH, HU, and CK breeds.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61342
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, XG,Wang, YR,Cao, XK,et al. Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds[J]. ANIMAL BIOTECHNOLOGY,2021.
APA	Wang, XG.,Wang, YR.,Cao, XK.,Huang, YZ.,Li, P.,...&Chen, H.(2021).Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds.ANIMAL BIOTECHNOLOGY.
MLA	Wang, XG,et al."Copy number variations of the KAT6A gene are associated with body measurements of Chinese sheep breeds".ANIMAL BIOTECHNOLOGY (2021).