Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep

NWIPB OpenIR

	Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep
	Tian, Dehong; Sun, De; Ren, Qianben; Zhang, Pei; Zhang, Zian; Zhang, Wenkui; Luo, Haizhou; Li, Xue; Han, Buying; Liu, Dehui; Zhao, Kai
	2023
发表期刊	SCIENTIFIC REPORTS
卷号	13 期号:1
摘要	Copy number variation (CNV) is a genetic structural polymorphism important for phenotypic diversity and important economic traits of livestock breeds, and it plays an important role in the desired genetic variation. This study used whole genome sequencing to detect the CNV variation in the genome of 6 local Tibetan sheep groups. We detected 69,166 CNV events and 7230 copy number variable regions (CNVRs) after merging the overlapping CNVs, accounting for 2.72% of the reference genome. The CNVR length detected ranged from 1.1 to 1693.5 Kb, with a total length of 118.69 Mb and an average length of 16.42 Kb per CNVR. Functional GO cluster analysis showed that the CNVR genes were mainly involved in sensory perception systems, response to stimulus, and signal transduction. Through CNVR-based Vst analysis, we found that the CACNA2D3 and CTBP1 genes related to hypoxia adaptation, the HTR1A gene related to coat color, and the TRNAS-GGA and PIK3C3 genes related to body weight were all strongly selected. The findings of our study will contribute novel insights into the genetic structural variation underlying hypoxia adaptation and economically important traits in Tibetan sheep.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61558
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Tian, Dehong,Sun, De,Ren, Qianben,et al. Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep[J]. SCIENTIFIC REPORTS,2023,13(1).
APA	Tian, Dehong.,Sun, De.,Ren, Qianben.,Zhang, Pei.,Zhang, Zian.,...&Zhao, Kai.(2023).Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep.SCIENTIFIC REPORTS,13(1).
MLA	Tian, Dehong,et al."Genome-wide identification of candidate copy number polymorphism genes associated with complex traits of Tibetan-sheep".SCIENTIFIC REPORTS 13.1(2023).