Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water

NWIPB OpenIR

	Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water
	Tian, Fei; Zhou, Bingzheng; Li, Xiaohuan; Zhang, Yu; Qi, Delin; Qi, Hongfang; Jiang, Huamin; Zhao, Kai; Liu, Sijia
	2023
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号	247
摘要	Understanding how evolutionary processes shape the genetic variations and influence the response of species to environmental alterations is critical for biodiversity conservation and molecular breeding. Gymnocypris prze-walskii przewalskii is the only known cyprinid fish that dwells in the brackish water of Lake Qinghai on the Qinghai-Tibetan Plateau. To reveal the genetic basis of its adaptation to high salinity and alkalinity, whole-genome sequencing was performed in G. p. przewalskii and its freshwater relatives Gymnocypris eckloni and Gymnocypris przewalskii ganzihonensis. Compared with freshwater species, lower genetic diversity and higher linkage disequilibrium were observed in G. p. przewalskii. Selective sweep analysis identified 424 core-selective genes enriched in transport activities. Transfection analysis showed that genetic changes in the positively selected gene aquaporin 3 (AQP3) improved cell viability after salt treatment, suggesting its involvement in brackish water adaptation. Our analysis indicates that ion and water transporter genes experienced intensive selection, which might have contributed to the maintenance of high osmolality and ion content in G. p. prze-walskii. The current study identified key molecules involved in the adaptation of fish to brackish water, providing valuable genomic resources for the molecular breeding of salt-tolerant fish.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61612
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Tian, Fei,Zhou, Bingzheng,Li, Xiaohuan,et al. Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,247.
APA	Tian, Fei.,Zhou, Bingzheng.,Li, Xiaohuan.,Zhang, Yu.,Qi, Delin.,...&Liu, Sijia.(2023).Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,247.
MLA	Tian, Fei,et al."Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 247(2023).