Marked variations in gut microbial diversity, functions, and disease risk between wild and captive alpine musk deer

NWIPB OpenIR

	Marked variations in gut microbial diversity, functions, and disease risk between wild and captive alpine musk deer
	Jiang, Feng; Song, Pengfei; Liu, Daoxin; Zhang, Jingjie; Qin, Wen; Wang, Haijing; Liang, Chengbo; Gao, Hongmei; Zhang, Tongzuo
	2023
发表期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷号	107 期号:17 页码:5517
摘要	Maintaining a healthy status is crucial for the successful captive breeding of endangered alpine musk deer (Moschus chrysogaster, AMD), and captive breeding programs are beneficial to the ex-situ conservation and wild population recovery of this species. Meanwhile, the gut microbiota is essential for host health, survival, and environmental adaptation. However, changes in feeding environment and food can affect the composition and function of gut microbiota in musk deer, ultimately impacting their health and adaptation. Therefore, regulating the health status of wild and captive AMD through a non-invasive method that targets gut microbiota is a promising approach. Here, 16S rRNA gene sequencing was employed to reveal the composition and functional variations between wild (N = 23) and captive (N = 25) AMD populations. The results indicated that the gut microbiota of wild AMD exhibited significantly higher alpha diversity (P < 0.001) and greater abundance of the phylum Firmicutes, as well as several dominant genera, including UCG-005, Christensenellaceae R7 group, Monoglobus, Ruminococcus, and Roseburia (P < 0.05), compared to captive AMD. These findings suggest that the wild AMD may possess more effective nutrient absorption and utilization, a more stable intestinal microecology, and better adaption to the complex natural environment. The captive individuals displayed higher metabolic functions with an increased abundance of the phylum Bacteroidetes and certain dominant genera, including Bacteroides, Rikenellaceae RC9 gut group, NK4A214 group, and Alistipes (P < 0.05), which contributed to the metabolic activities of various nutrients. Furthermore, captive AMD showed a higher level of 11 potential opportunistic pathogens and a greater enrichment of disease-related functions compared to wild AMD, indicating that wild musk deer have a lower risk of intestinal diseases and more stable intestinal structure in comparison to captive populations. These findings can serve as a valuable theoretical foundation for promoting the healthy breeding of musk deer and as a guide for evaluating the health of wild-released and reintroduced musk deer in the future.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61616
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Jiang, Feng,Song, Pengfei,Liu, Daoxin,et al. Marked variations in gut microbial diversity, functions, and disease risk between wild and captive alpine musk deer[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2023,107(17):5517.
APA	Jiang, Feng.,Song, Pengfei.,Liu, Daoxin.,Zhang, Jingjie.,Qin, Wen.,...&Zhang, Tongzuo.(2023).Marked variations in gut microbial diversity, functions, and disease risk between wild and captive alpine musk deer.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,107(17),5517.
MLA	Jiang, Feng,et al."Marked variations in gut microbial diversity, functions, and disease risk between wild and captive alpine musk deer".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 107.17(2023):5517.