Maternal urinary metal(loid)s and risk of preterm birth: A cohort study in the Tibetan Plateau

NWIPB OpenIR

	Maternal urinary metal(loid)s and risk of preterm birth: A cohort study in the Tibetan Plateau
	Zhao, Lei; Wang, Shulin; Liu, Miao; Cao, Zhongqiang; Xiao, Yuancan; Wang, Pinhua; Jiangcuo, Zhaxi; Jian, Wenxiu; Zhang, Yangrui; Xu, Ruihua; Wang, Xuejun; Peng, Wen
	2023
发表期刊	ENVIRONMENTAL POLLUTION
卷号	333
摘要	Maternal metal(loid)s exposure has been related to preterm birth (PTB), but the results are still inconclusive. Previous studies have mainly discussed the harmful metal(loid)s, neglecting beneficial ones. We examined the association of maternal metal(loid)s with PTB and gestational age (GA) in a birth cohort from the Tibetan Plateau. We measured 29 metal(loid)s in urine samples from 1081 pregnant women in the third trimester. Information regarding demographics, socioeconomic status, diet, medication, and lifestyle was collected through standardized interviews. The associations of single metal(loid)s with PTB or GA were evaluated using a generalized linear mixed-effects model or linear mixed-effects model. Elastic net and Bayesian kernel machine regressions were used to explore the joint associations. Magnesium (Mg), Copper (Cu), and Tin (Sn) were the main harmful metal(loid)s positively and negatively associated with PTB or GA, respectively. Mg was the dominant harmful metal(loid)s associated with PTB in a J-shape. A one-fold increase in Mg was associated with a 38% increased risk of PTB [OR (95% CI) = 1.38 (1.15, 1.65), PFDR<0.05) and 0.17 weeks shortening of GA [13 (95% CI) =-0.25 (-0.35,-0.14), PFDR<0.05). Cesium (Cs), rubidium (Rb), and Molybdenum (Mo) were the main beneficial metals. Cs dominated the beneficial associations and was negatively associated with PTB in a linear manner. A one-fold increase in Cs was associated with a 67% decreased risk of PTB [OR (95% CI) = 0.43 (0.27, 0.67), PFDR<0.05) and 0.24 weeks of prolonged GA [13 (95% CI) = 0.35 (0.13, 0.56), PFDR<0.05). Ethnicity and living altitude modified the association of Mg and Cu with PTB or GA. In conclusion, Maternal urinary metal(loid)s were bi-directionally associated with PTB in a population in the Tibetan Plateau. Mg and Cs were the dominant harmful and beneficial metal(loid)s, respectively.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61624
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhao, Lei,Wang, Shulin,Liu, Miao,et al. Maternal urinary metal(loid)s and risk of preterm birth: A cohort study in the Tibetan Plateau[J]. ENVIRONMENTAL POLLUTION,2023,333.
APA	Zhao, Lei.,Wang, Shulin.,Liu, Miao.,Cao, Zhongqiang.,Xiao, Yuancan.,...&Peng, Wen.(2023).Maternal urinary metal(loid)s and risk of preterm birth: A cohort study in the Tibetan Plateau.ENVIRONMENTAL POLLUTION,333.
MLA	Zhao, Lei,et al."Maternal urinary metal(loid)s and risk of preterm birth: A cohort study in the Tibetan Plateau".ENVIRONMENTAL POLLUTION 333(2023).