Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production

NWIPB OpenIR

	Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production
	Cao, Jing-Ya; Wang, Zhi-Yao; Stewart, Alan J. J.; Dong, Qi; Zhao, Ye; Mei, Li-Juan; Tao, Yan-Duo; Yu, Rui-Tao
	2023
发表期刊	PLANTA MEDICA
卷号	89 期号:6 页码:663
摘要	Five new diarylbutyrolactones and sesquilignans ( 1a/1b - 4 ), including one pair of enantiomers ( 1a/1b ), together with 10 known analogues ( 5 - 14 ), were isolated from the whole plants of Saussurea medusa . Compound 1 was found to possess an unusual 7,8 ' -diarylbutyrolactone lignan structure. Separation by chiral HPLC analysis led to the isolation of one pair of enantiomers, (+)- 1a and (-)- 1b . The structures of the new compounds were elucidated by extensive spectroscopic data. All compounds, except compounds 5, 7 and 9 , were isolated from S. medusa for the first time. Moreover, compounds 1 - 4, 8 and 10 - 14 had never been obtained from the genus Saussurea previously. Compounds (+)- 1a, 2, 5, 7 , and 9 - 11 were found to inhibit the lipopolysaccharide (LPS)-induced release of NO by RAW264.7 cells with IC (50) values ranging from 10.1 +/- 1.8 to 41.7 +/- 2.1 mu M. Molecular docking and iNOS expression experiments were performed to examine the interactions between the active compounds and the iNOS enzyme.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61713
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Cao, Jing-Ya,Wang, Zhi-Yao,Stewart, Alan J. J.,et al. Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production[J]. PLANTA MEDICA,2023,89(6):663.
APA	Cao, Jing-Ya.,Wang, Zhi-Yao.,Stewart, Alan J. J..,Dong, Qi.,Zhao, Ye.,...&Yu, Rui-Tao.(2023).Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production.PLANTA MEDICA,89(6),663.
MLA	Cao, Jing-Ya,et al."Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production".PLANTA MEDICA 89.6(2023):663.