ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice

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	ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice
	Wang, Yu-Jun; Li, Shuang; Tao, Hai-Ping; Zhang, Xiao-Na; Fang, You-Gui; Yang, Qi-En
	2023
发表期刊	REPRODUCTIVE BIOLOGY
卷号	23 期号:1
摘要	Spermatogenesis is a continual process that relies on the activities of undifferentiated spermatogonia, which contain spermatogonial stem cells (SSCs) that serve as the basis of spermatogenesis. The gene expression pattern and molecular control of fate decisions of undifferentiated spermatogonia are not well understood. Rho guanine nucleotide exchange factor 15 (ARHGEF15, also known as EPHEXIN5) is a guanine nucleotide-exchange factor (GEF) that activates the Rho protein. Here, we reported that ARHGEF15 was expressed in undifferentiated spermatogonia and spermatocytes in mouse testes; however, its deletion did not affect spermatogenesis. Arh- gef15-/-mice were fertile, and histological examination of the seminiferous tubules of Arhgef15-/-mice revealed complete spermatogenesis with the presence of all types of spermatogenic cells. Proliferation and differentiation of the undifferentiated spermatogonia were not impacted; however, further analysis showed that Arhgef15 deletion resulted in decreased expression of Nanos2, Lin28a and Ddx4. Together, these findings suggest that ARHGEF15 was specifically enriched in undifferentiated spermatogonia and regulated gene expression but dispensable for spermatogenesis in mice.
收录类别	SCIE
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/61718
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, Yu-Jun,Li, Shuang,Tao, Hai-Ping,et al. ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice[J]. REPRODUCTIVE BIOLOGY,2023,23(1).
APA	Wang, Yu-Jun,Li, Shuang,Tao, Hai-Ping,Zhang, Xiao-Na,Fang, You-Gui,&Yang, Qi-En.(2023).ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice.REPRODUCTIVE BIOLOGY,23(1).
MLA	Wang, Yu-Jun,et al."ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice".REPRODUCTIVE BIOLOGY 23.1(2023).