Chemical Species, Micromorphology, and XRD Fingerprint Analysis of Tibetan Medicine Zuotai Containing Mercury

doi:10.1155/2016/7010519

NWIPB OpenIR

	Chemical Species, Micromorphology, and XRD Fingerprint Analysis of Tibetan Medicine Zuotai Containing Mercury
	Li, Cen 1,2; Yang, Hongxia 1,2; Du, Yuzhi 1,2; Xiao, Yuancan 1,2; Zhandui 3; Sanglao 4; Wang, Zhang 5; Ladan, Duojie 6; Bi, Hongtao 1,2; Wei, Lixin 1,2
	2016
发表期刊	BIOINORGANIC CHEMISTRY AND APPLICATIONS
文章类型	Article
摘要	Zuotai (gTso thal) is one of the famous drugs containing mercury in Tibetan medicine. However, little is known about the chemical substance basis of its pharmacodynamics and the intrinsic link of different samples sources so far. Given this, energy dispersive spectrometry of X-ray (EDX), scanning electron microscopy (SEM), atomic force microscopy (AFM), and powder X-ray diffraction (XRD) were used to assay the elements, micromorphology, and phase composition of nine Zuotai samples from different regions, respectively; the XRD fingerprint features of Zuotai were analyzed by multivariate statistical analysis. EDX result shows that Zuotai contains Hg, S, O, Fe, Al, Cu, and other elements. SEM and AFM observations suggest that Zuotai is a kind of ancient nanodrug. Its particles are mainly in the range of 100-800 nm, which commonly further aggregate into 1-30 mu m loosely amorphous particles. XRD test shows that beta-HgS, S-8, and alpha-HgS are its main phase compositions. XRD fingerprint analysis indicates that the similarity degrees of nine samples are very high, and the results of multivariate statistical analysis are broadly consistent with sample sources. The present research has revealed the physicochemical characteristics of Zuotai, and it would play a positive role in interpreting this mysterious Tibetan drug.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1155/2016/7010519
关键词[WOS]	NEAR-INFRARED SPECTROSCOPY ; ORAL DELIVERY ; NANOPARTICLES ; IDENTIFICATION
收录类别	SCI
语种	英语
项目资助者	"The Dawn of West China" Talent Training Program of the Chinese Academy of Sciences(Y529021211) ; National Natural Science Foundation of China(81374063) ; Science Foundation for Young Scholars of Qinghai Province(2016-ZJ-919Q)
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear ; Chemistry, Organic
WOS记录号	WOS:000385063100001
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6401
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Pharmacol & Safety Evaluat Key Lab Tibetan Med Qi, Xining 810008, Qinghai, Peoples R China 2.Chinese Acad Sci, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China 3.Tibetan Tradit Med Coll, Lhasa 850000, Tibet, Peoples R China 4.Gansu Prov Acad Tibetan Med, Hezuo 747000, Gansu, Peoples R China 5.Aba Prefecture Tibetan Med Hosp, Maerkang 624000, Sichuan, Peoples R China 6.Qinghai Prov Tibetan Med Hosp, Xining 810007, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Cen,Yang, Hongxia,Du, Yuzhi,et al. Chemical Species, Micromorphology, and XRD Fingerprint Analysis of Tibetan Medicine Zuotai Containing Mercury[J]. BIOINORGANIC CHEMISTRY AND APPLICATIONS,2016.
APA	Li, Cen.,Yang, Hongxia.,Du, Yuzhi.,Xiao, Yuancan.,Zhandui.,...&Wei, Lixin.(2016).Chemical Species, Micromorphology, and XRD Fingerprint Analysis of Tibetan Medicine Zuotai Containing Mercury.BIOINORGANIC CHEMISTRY AND APPLICATIONS.
MLA	Li, Cen,et al."Chemical Species, Micromorphology, and XRD Fingerprint Analysis of Tibetan Medicine Zuotai Containing Mercury".BIOINORGANIC CHEMISTRY AND APPLICATIONS (2016).