Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice

doi:10.1016/j.toxlet.2016.10.003

NWIPB OpenIR

	Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice
	Liu, Jie 1; Lu, Yuan-Fu 1; Li, Wen-Kai 1; Zhou, Zheng-Ping 1; Li, Ying-Ying 1; Yang, Xi 1; Li, Cen 2; Du, Yu-Zhi 2; Wei, Li-Xin 2
	2016-11-16
发表期刊	TOXICOLOGY LETTERS
卷号	262 页码:153-160
文章类型	Article
摘要	Mercury sulfides (alpha-HgS, beta-HgS) are frequently included in traditional medicines. Mercury is known for nephrotoxicity, their safety is of concern. To address this question, mice were orally administrated with Zuotai (54% beta-HgS, 30 mg/kg), alpha-HgS (HgS, 30 mg/kg), HgCl2 (33.6 mg/kg), or MeHgCl (3.1 mg/kg) for 7 days, and nephrotoxicity was examined. Animal body weights were decreased by HgCl2 and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. HgCl2 and MeHg produced renal tubular vacuolation, interstitial inflammation and cell degeneration with protein cysts in the tubular lumen, while these pathological lesions were mild in Zuotai and HgS-treated mice. Electron microscopy showed that HgCl2 and MeHg produced spotted swelling endothelium reticulum, while these lesions were mild or absent in Zuotai and HgS-treated mice. Renal Hg contents reached 250-300 ng/mg kidney in HgCl2 and MeHg groups as compared to 2-3 ng/mg in Zuotai and HgS groups. The expression of kidney injury biomarkers, kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (Ngal), were increased after HgCl2 and MeHg, but unaltered after Zuotai and HgS. The expression of renal influx transporters Oat3 and Oatp4c1 was decreased, while the expression of renal efflux transporter such as Mrp2, Mrp4, and Mate2 was increased following HgCl2 and MeHg. These gene expressions were unchanged after Zuotai and HgS. In summary, both alpha-HgS and beta-HgS are less nephrotoxic than HgCl2 and MeHg, indicating that chemical forms of mercury are a major determinant of mercury disposition and toxicity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
关键词	Mercury Sulfides Mercury Chloride Methylmercury Nephrotoxicity Electromicrospy Renal Hg Renal Transporter Kim-1 Oatp4c1 Mrp2
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.toxlet.2016.10.003
关键词[WOS]	TIBETAN MEDICINE ZUOTAI ; AYURVEDIC MEDICINES ; PROXIMAL TUBULE ; RATS ; TRANSPORTERS ; CINNABAR ; ACID
收录类别	SCI
语种	英语
项目资助者	Key Laboratory Special Development Program of Qinghai Province(2014-Z-Y02) ; Chinese National Science Foundation(81374063)
WOS研究方向	Toxicology
WOS类目	Toxicology
WOS记录号	WOS:000386071200018
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6420
专题	中国科学院西北高原生物研究所
作者单位	1.Zunyi Med Coll, Zunyi, Peoples R China 2.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jie,Lu, Yuan-Fu,Li, Wen-Kai,et al. Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice[J]. TOXICOLOGY LETTERS,2016,262:153-160.
APA	Liu, Jie.,Lu, Yuan-Fu.,Li, Wen-Kai.,Zhou, Zheng-Ping.,Li, Ying-Ying.,...&Wei, Li-Xin.(2016).Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice.TOXICOLOGY LETTERS,262,153-160.
MLA	Liu, Jie,et al."Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice".TOXICOLOGY LETTERS 262(2016):153-160.