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Direct and indirect fluorescent detection of tetracyclines using dually emitting carbon dots
Qu, Fei1,2; Sun, Zhe1,2; Liu, Dongya1,2; Zhao, Xianen1,2; You, Jinmao1,2,3
2016-09-01
Source PublicationMICROCHIMICA ACTA
Volume183Issue:9Pages:2547-2553
SubtypeArticle
AbstractThe authors describe dual-emission carbon nanodots containing blue emitters (BE; peak emission at 385nm under 315 nm excitation) and yellow emitters (YE; peak emission at 530 nm under 365nm excitation), and how they can be applied to direct and indirect determination of tetracyclines (TCs). The direct detection scheme is based on the finding that tetracycline (TET), oxytetracycline, chlortetracycline and doxycycline quench the two emissions of the carbon dots. While direct determination is rapid and convenient, it cannot differentiate between TCs. The indirect detection scheme, in contrast, is based on the finding that Al (III) ions enhance the fluorescence of the YE in the carbon dots, and that they cause a blue shift in emission. It is, however, known that TET forms a strong complex with Al (III), and this can inhibit the interaction between Al (III) and the YE, so that the fluorescence of YE is not enhanced and blue-shifted by Al (III) in the presence of TET. This finding is exploited in a fluorescence turn-on/off assay for TET that can distinguish TET from other TCs. The linear range of indirect determination for TET extends from 1 nM to 30 mu M, and the limit of detection is 0.52 nM. The indirect method was successfully applied to the determination of TET in spiked milk, fish and pork, and recoveries ranged from 91.7 to 102 %.
KeywordTetracycline Oxytetracycline Chlortetracycline Doxycycline Fluorometry Quenching
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1007/s00604-016-1901-9
WOS KeywordENHANCED-FLUORESCENCE ; QUANTUM DOTS ; OXYTETRACYCLINE ; RESIDUES ; PROBES ; NANOPARTICLES ; COPPER(II) ; NANODOTS ; IONS ; MILK
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China (Youth Fund Project)(21405093) ; Scientific Research Foundation of Qufu Normal University(BSQD20130117)
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000381401300008
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/6428
Collection中国科学院西北高原生物研究所
Affiliation1.Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
2.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
3.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810001, Peoples R China
Recommended Citation
GB/T 7714
Qu, Fei,Sun, Zhe,Liu, Dongya,et al. Direct and indirect fluorescent detection of tetracyclines using dually emitting carbon dots[J]. MICROCHIMICA ACTA,2016,183(9):2547-2553.
APA Qu, Fei,Sun, Zhe,Liu, Dongya,Zhao, Xianen,&You, Jinmao.(2016).Direct and indirect fluorescent detection of tetracyclines using dually emitting carbon dots.MICROCHIMICA ACTA,183(9),2547-2553.
MLA Qu, Fei,et al."Direct and indirect fluorescent detection of tetracyclines using dually emitting carbon dots".MICROCHIMICA ACTA 183.9(2016):2547-2553.
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