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Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
Zheng, Wei1,2; Wang, Qilan3; Lu, Xiaohua1; Shi, Qiangqiang3; Zou, Junhui1; Tao, Yanduo3; Wang, Pu1
2016
Source PublicationMEDIATORS OF INFLAMMATION
SubtypeArticle
AbstractDracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in ConcanavalinA- (ConA-) induced hepatitis (CIH). DH recruitedmore CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1155/2016/2684321
WOS KeywordSYNERGISTIC LIVER-INJURY ; SUPPRESSOR-CELLS ; BACTERIAL LIPOPOLYSACCHARIDE ; KUPFFER CELLS ; CANCER ; MONOCROTALINE ; INFLAMMATION ; INFECTION ; CYTOKINES ; EXPOSURE
Indexed BySCI
Language英语
Funding OrganizationKey Project of Science and Technology of Qinghai(2014-GX-220) ; Project of Science and Technology of Guangdong(2013B010404039) ; State Key Laboratory of Veterinary Etiological Biology(SKLVEB2015KFKT004) ; Shenzhen Science and Technology Program(JCYJ20130401170306850 ; Shenzhen Peacock Next Generation Monoclonal Antibody Drug Research and Development Program(KQTD201210) ; JCYJ20150401145529036 ; JCYJ20150521094519486)
WOS Research AreaCell Biology ; Immunology
WOS SubjectCell Biology ; Immunology
WOS IDWOS:000381138700001
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/6440
Collection中国科学院西北高原生物研究所
Affiliation1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
2.Acad Mil Med Sci, Inst Mil Vet Med, Changchun 130122, Peoples R China
3.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining 810001, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Wei,Wang, Qilan,Lu, Xiaohua,et al. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis[J]. MEDIATORS OF INFLAMMATION,2016.
APA Zheng, Wei.,Wang, Qilan.,Lu, Xiaohua.,Shi, Qiangqiang.,Zou, Junhui.,...&Wang, Pu.(2016).Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.MEDIATORS OF INFLAMMATION.
MLA Zheng, Wei,et al."Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis".MEDIATORS OF INFLAMMATION (2016).
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