New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus

doi:10.1016/j.tet.2016.06.061

NWIPB OpenIR

	New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus
	Wang, Yan-Ming 1,2,5; Zhao, Jian-Qiang 3,5; Zhou, Shuang-Yan 4; Yang, Jun-Li 1,2; Yao, Xiao-Jun 4; Tao, Yan-Duo 3; Mei, Li-Juan 3; Shi, Yan-Ping 1,2
	2016-08-11
发表期刊	TETRAHEDRON
卷号	72 期号:32 页码:4910-4917
文章类型	Article
摘要	Phytochemical investigation on Asterothamnus centrali-asiaticus afforded four new sesquiterpenes, asterothamnones A-D (1-4), and three new benzofuran derivatives (5-7) together with ten known compounds (8-17). Their structures were elucidated using 1D and 2D NMR and X-ray diffraction analyses. Compounds 1-4 were verified to be unusual eudesmane sesquiterpenes possessing 4,6-dien-3-one or 1,4,6-triene-3-one conjugated system. The absolute configurations of compounds 1-8 were established by means of calculated electronic circular dichroism (ECD). Furthermore, all isolates were evaluated for their cytotoxic and anti-oxidant activities. Results showed that 10, 12 and, 14 exhibited cytotoxic activity against HepG2 cancer cells and 14 displayed cytotoxicity against MGC-803 cancer cells. Compounds 10 and 17 showed anti-oxidant effect. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Asterothamnus Centrali-asiaticus Sesquiterpenes Asterothamnones Benzofuran Derivatives
WOS标题词	Science & Technology ; Physical Sciences
DOI	10.1016/j.tet.2016.06.061
关键词[WOS]	ABSOLUTE-CONFIGURATION ; CHEMICAL-CONSTITUENTS ; FLOWERS ; GLUCOSIDES
收录类别	SCI
语种	英语
项目资助者	National Nature Science Foundation of China(21375136 ; scientific research project of Central Asia Drug Discovery and Development Centre of Chinese Academy of Sciences(CAM201404) ; CAS Pioneer Hundred Talents Program ; 21575150)
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000380604100018
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6462
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources CAS, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Peoples R China 4.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yan-Ming,Zhao, Jian-Qiang,Zhou, Shuang-Yan,et al. New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus[J]. TETRAHEDRON,2016,72(32):4910-4917.
APA	Wang, Yan-Ming.,Zhao, Jian-Qiang.,Zhou, Shuang-Yan.,Yang, Jun-Li.,Yao, Xiao-Jun.,...&Shi, Yan-Ping.(2016).New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus.TETRAHEDRON,72(32),4910-4917.
MLA	Wang, Yan-Ming,et al."New sesquiterpenes and benzofuran derivatives from the aerial parts of Asterothamnus centrali-asiaticus".TETRAHEDRON 72.32(2016):4910-4917.