NWIPB OpenIR
Computational probing protein-protein interactions targeting small molecules
Wang, Yong-Cui1; Chen, Shi-Long1; Deng, Nai-Yang2; Wang, Yong3
2016-01-15
发表期刊BIOINFORMATICS
卷号32期号:2页码:226-234
文章类型Article
摘要Motivation: With the booming of interactome studies, a lot of interactions can be measured in a high throughput way and large scale datasets are available. It is becoming apparent that many different types of interactions can be potential drug targets. Compared with inhibition of a single protein, inhibition of protein-protein interaction (PPI) is promising to improve the specificity with fewer adverse side-effects. Also it greatly broadens the drug target search space, which makes the drug target discovery difficult. Computational methods are highly desired to efficiently provide candidates for further experiments and hold the promise to greatly accelerate the discovery of novel drug targets.
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences
DOI10.1093/bioinformatics/btv528
关键词[WOS]INTERACTION NETWORK ; DRUG DISCOVERY ; INTERACTION PREDICTION ; INTERACTION MAP ; KERNEL METHODS ; DATABASE ; INHIBITORS ; SEQUENCE ; MACHINE ; IDENTIFICATION
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(11201470 ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)(XDB13040700) ; 31270270 ; 61171007 ; 11422108 ; 11131009 ; 11371365)
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
WOS类目Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability
WOS记录号WOS:000368360100010
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/6500
专题中国科学院西北高原生物研究所
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China
2.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,et al. Computational probing protein-protein interactions targeting small molecules[J]. BIOINFORMATICS,2016,32(2):226-234.
APA Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,&Wang, Yong.(2016).Computational probing protein-protein interactions targeting small molecules.BIOINFORMATICS,32(2),226-234.
MLA Wang, Yong-Cui,et al."Computational probing protein-protein interactions targeting small molecules".BIOINFORMATICS 32.2(2016):226-234.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yong-Cui]的文章
[Chen, Shi-Long]的文章
[Deng, Nai-Yang]的文章
百度学术
百度学术中相似的文章
[Wang, Yong-Cui]的文章
[Chen, Shi-Long]的文章
[Deng, Nai-Yang]的文章
必应学术
必应学术中相似的文章
[Wang, Yong-Cui]的文章
[Chen, Shi-Long]的文章
[Deng, Nai-Yang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。