Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Computational probing protein-protein interactions targeting small molecules | |
Wang, Yong-Cui1; Chen, Shi-Long1; Deng, Nai-Yang2; Wang, Yong3 | |
2016-01-15 | |
发表期刊 | BIOINFORMATICS |
卷号 | 32期号:2页码:226-234 |
文章类型 | Article |
摘要 | Motivation: With the booming of interactome studies, a lot of interactions can be measured in a high throughput way and large scale datasets are available. It is becoming apparent that many different types of interactions can be potential drug targets. Compared with inhibition of a single protein, inhibition of protein-protein interaction (PPI) is promising to improve the specificity with fewer adverse side-effects. Also it greatly broadens the drug target search space, which makes the drug target discovery difficult. Computational methods are highly desired to efficiently provide candidates for further experiments and hold the promise to greatly accelerate the discovery of novel drug targets. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences |
DOI | 10.1093/bioinformatics/btv528 |
关键词[WOS] | INTERACTION NETWORK ; DRUG DISCOVERY ; INTERACTION PREDICTION ; INTERACTION MAP ; KERNEL METHODS ; DATABASE ; INHIBITORS ; SEQUENCE ; MACHINE ; IDENTIFICATION |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Natural Science Foundation of China(11201470 ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)(XDB13040700) ; 31270270 ; 61171007 ; 11422108 ; 11131009 ; 11371365) |
WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics |
WOS类目 | Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability |
WOS记录号 | WOS:000368360100010 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/6500 |
专题 | 中国科学院西北高原生物研究所 |
作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,et al. Computational probing protein-protein interactions targeting small molecules[J]. BIOINFORMATICS,2016,32(2):226-234. |
APA | Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,&Wang, Yong.(2016).Computational probing protein-protein interactions targeting small molecules.BIOINFORMATICS,32(2),226-234. |
MLA | Wang, Yong-Cui,et al."Computational probing protein-protein interactions targeting small molecules".BIOINFORMATICS 32.2(2016):226-234. |
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