NWIPB OpenIR
Computational probing protein-protein interactions targeting small molecules
Wang, Yong-Cui1; Chen, Shi-Long1; Deng, Nai-Yang2; Wang, Yong3
2016-01-15
Source PublicationBIOINFORMATICS
Volume32Issue:2Pages:226-234
SubtypeArticle
AbstractMotivation: With the booming of interactome studies, a lot of interactions can be measured in a high throughput way and large scale datasets are available. It is becoming apparent that many different types of interactions can be potential drug targets. Compared with inhibition of a single protein, inhibition of protein-protein interaction (PPI) is promising to improve the specificity with fewer adverse side-effects. Also it greatly broadens the drug target search space, which makes the drug target discovery difficult. Computational methods are highly desired to efficiently provide candidates for further experiments and hold the promise to greatly accelerate the discovery of novel drug targets.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences
DOI10.1093/bioinformatics/btv528
WOS KeywordINTERACTION NETWORK ; DRUG DISCOVERY ; INTERACTION PREDICTION ; INTERACTION MAP ; KERNEL METHODS ; DATABASE ; INHIBITORS ; SEQUENCE ; MACHINE ; IDENTIFICATION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(11201470 ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)(XDB13040700) ; 31270270 ; 61171007 ; 11422108 ; 11131009 ; 11371365)
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
WOS SubjectBiochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability
WOS IDWOS:000368360100010
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/6500
Collection中国科学院西北高原生物研究所
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China
2.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,et al. Computational probing protein-protein interactions targeting small molecules[J]. BIOINFORMATICS,2016,32(2):226-234.
APA Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,&Wang, Yong.(2016).Computational probing protein-protein interactions targeting small molecules.BIOINFORMATICS,32(2),226-234.
MLA Wang, Yong-Cui,et al."Computational probing protein-protein interactions targeting small molecules".BIOINFORMATICS 32.2(2016):226-234.
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