Thermo-chemical modification to produce citric acid-yeast superabsorbent composites for ketoprofen delivery

doi:10.1039/c5ra23577d

NWIPB OpenIR

	Thermo-chemical modification to produce citric acid-yeast superabsorbent composites for ketoprofen delivery
	Feng, Diejing 1; Bai, Bo 2; Wang, Honglun 2; Suo, Yourui 2
	2015
发表期刊	RSC ADVANCES
卷号	5 期号:127 页码:104756-104768
文章类型	Article
摘要	Owing to their unique physicochemical/biological properties and natural abundance, native yeast microbes were used to prepare a novel eco-friendly superabsorbent composite through thermo-chemical modification of yeast with citric acid in semi-dry conditions. The structure and morphology of the as-produced citric acid-yeast superabsorbent composites were characterized by Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), respectively. The surface characteristics were studied systematically, including carboxyl content, degree of esterification, degree of substitution and zeta potential. The detailed formation mechanism was proposed. The evaluation of equilibrium welling showed that the species were able to absorb up to 38 times their weight in distilled water, and the water absorption capacity was affected by reaction temperature and external solution (the charge number, salt concentration and pH value). The results implied that citric acid-yeast superabsorbent composites exhibited enhanced water absorption, salt tolerance and pH sensitivity. The excellent swelling performance and special functional groups allowed the citric acid-yeast composites to target drug delivery. Ketoprofen, as a model drug, was utilized to monitor the loading and cumulative release efficiency to evaluate the suitability of citric acid-yeast composites as drug carriers. Its pH-sensitivity, biocompatibility and degradability make it a potential candidate for drug delivery.
WOS标题词	Science & Technology ; Physical Sciences
DOI	10.1039/c5ra23577d
关键词[WOS]	PH-SENSITIVE HYDROGELS ; CORN PROTEIN PRODUCTS ; CELL-WALL COMPOSITION ; ORAL-DRUG DELIVERY ; CROSS-LINKING ; BETA-CYCLODEXTRIN ; CARBOXYLIC-ACIDS ; IN-VITRO ; STARCH ; SYSTEMS
收录类别	SCI
语种	英语
项目资助者	Shaanxi Provincial Natural Science Foundation of China(2015JM2071) ; National Natural Science Foundation of China(21176031) ; Fundamental Research Funds for the Central Universities(2014G3292007)
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000366865900017
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6516
专题	中国科学院西北高原生物研究所
作者单位	1.Changan Univ, Coll Environm Sci & Engn, Xian 710054, Peoples R China 2.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Tibetan Med Res, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Feng, Diejing,Bai, Bo,Wang, Honglun,et al. Thermo-chemical modification to produce citric acid-yeast superabsorbent composites for ketoprofen delivery[J]. RSC ADVANCES,2015,5(127):104756-104768.
APA	Feng, Diejing,Bai, Bo,Wang, Honglun,&Suo, Yourui.(2015).Thermo-chemical modification to produce citric acid-yeast superabsorbent composites for ketoprofen delivery.RSC ADVANCES,5(127),104756-104768.
MLA	Feng, Diejing,et al."Thermo-chemical modification to produce citric acid-yeast superabsorbent composites for ketoprofen delivery".RSC ADVANCES 5.127(2015):104756-104768.