NWIPB OpenIR
Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry
Che, Dandan1; Sun, Zhiwei1; Cheng, Jie1; Dou, Kun1; Ji, Zhongyin2,3; Chen, Guang3; Li, Guoliang3; You, Jinmao2,3
2017
Source PublicationMICROCHEMICAL JOURNAL
Volume130Pages:420-427
SubtypeArticle
AbstractWe have established an isotope labeling protocol for determining parabens in wastewater, based on a pair of isotope-coded derivatization reagents, by high performance liquid chromatography (LC) and electrospray mass spectrometry (ESI-MS). The pair of reagents used in our work were d(0)-10-methylacridone-2-sulfonyl chloride (d(0)-MASC, light form) and d(3)-10-methylacridone-2-sulfonyl chloride (d(3)-MASC, heavy form). d(0)-MASC and d(3)-MASC could easily derivatize parabens at 55 degrees C for 7.5 min in the mixture of bicarbonate and acetonitrile (1:1 v/v). It is shown that the derivatization offers 1-2 orders of magnitude signal enhancement over underivatized counterparts. The global isotope internal standard technology was employed for quantification analysis with d(3)-MASC-paraben as internal standard for corresponding d(0)-MASC-paraben. In addition, homologous internal standard was simultaneously used to correct derivatization processes. The obtained double internal standard calibration curves for parabens were linear over the range of 1-500 nmol L-1 (r > 0.997). The isotope coded derivatization based quantification method was precise and practical with RSD <= 3.6% and accuracy ranged 96.5 to 104.7%. The proposed method has also been successfully applied to the quantification of parabens in domestic sewage samples with precisions <= 5.2% and recoveries >= 87.9%. Five kinds of paraben including methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben were detected in the tested samples. The quantitative results indicated that parabens were at nmol L-1 level or lower, and ethylparaben were the most abundant, followed by methylparaben, propylparaben and butylparaben. It has been demonstrated that the isotope-coded derivatization reagents are useful for accurate quantification of analytes having target functional groups in real samples. (C) 2016 Elsevier B.V. All rights reserved.
KeywordIsotope-coded Derivatization Reagent Parabens High Performance Liquid Chromatography Mass Spectrometry
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.microc.2016.10.026
WOS KeywordBAR SORPTIVE EXTRACTION ; SOLID-PHASE DISPERSION ; RELATIVE QUANTIFICATION ; METHYL TRICLOSAN ; FATTY-ACIDS ; METABOLITES ; WATER ; REAGENTS ; SAMPLES ; MS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(21305076 ; National Natural Science Foundation of Shandong Province(ZR2015CM040) ; 21475075 ; 21475074 ; 21275089 ; 21677085)
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000390072400058
Citation statistics
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/6645
Collection中国科学院西北高原生物研究所
Affiliation1.Qufu Normal Univ, Key Lab Life Organ Anal Shandong Prov, Qufu 273165, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Peoples R China
3.Key Lab Pharmaceut Intermediates & Nat Prod, Qufu 273165, Peoples R China
Recommended Citation
GB/T 7714
Che, Dandan,Sun, Zhiwei,Cheng, Jie,et al. Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry[J]. MICROCHEMICAL JOURNAL,2017,130:420-427.
APA Che, Dandan.,Sun, Zhiwei.,Cheng, Jie.,Dou, Kun.,Ji, Zhongyin.,...&You, Jinmao.(2017).Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry.MICROCHEMICAL JOURNAL,130,420-427.
MLA Che, Dandan,et al."Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry".MICROCHEMICAL JOURNAL 130(2017):420-427.
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