Knowledge Management System of Northwest Institute of Plateau Biology, CAS
In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom. | |
Zhou, Wenna1,2; Xu, Heng1,2; Luan, Guangxiang1,2; Wang, HongLun1; Wang, Xiaoyan1; Ji, Mingkai3 | |
2016 | |
发表期刊 | SKIN PHARMACOLOGY AND PHYSIOLOGY |
卷号 | 29期号:5页码:243-249 |
文章类型 | Article |
摘要 | Aim: The objective of this study was to evaluate the effects of seed oil of Caragana korshinskii Kom. against Trichophyton mentagrophytes on an in vivo guinea pig model of dermatophytosis. Methods: The skin of albino guinea pigs was infected with T. mentagrophytes, and the animals were divided into five groups: negative control (NC group), positive control (PC group), vehicle control, CK50% group (received topical 50% seed oil of C korshinskii), and CK100% group (received topical 100% seed oil of C korshinskii). Evaluation of clinical efficacy was performed 72 h after the completion of a 10-day treatment regimen. Skin biopsy samples were processed for histopathological examination. Results: The infected untreated control guinea pigs showed patches of hair loss and ulcerated or scaly skin. Lower clinical scores indicate improved efficacy compared with NC. The lesion scores significantly declined in the CK50%, CK100%, and PC groups in comparison with the NC group. The CK50% group (45.31%) and the CK100% group (75%) showed clinical efficacy compared with the PC group (78.13%). In addition, no fungal elements, inflammation, or tissue destruction was observed in any of the PAS-stained sections of the infected skin in the groups treated with CK100% or 1% terbinafine. Conclusion: Seed oil of C. korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis. (C) 2016 S. Karger AG, Basel |
关键词 | Caragana Korshinskii Kom. Trichophyton Mentagrophytes Guinea Pig Model Antifungal Agent Histopathology |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1159/000448739 |
关键词[WOS] | MICRODILUTION METHOD M38-A ; ANTIFUNGAL DRUGS ; DERMATOPHYTOSIS ; MENTAGROPHYTES ; SUSCEPTIBILITY ; RUBRUM ; MODEL ; TRANSFERRIN ; QUINCKEANUM ; EFFICACY |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | Key Program of 'The Dawn of West China' Talent Foundation of the Chinese Academy of Sciences ; National Natural Science Foundation of China(31470426 ; Qinghai Provincial Natural Science Foundation(2015-ZJ-728 ; Youth Innovation Promotion Association, Chinese Academy of Sciences(2013277) ; 31300292) ; 2015-SF-121 ; 2014-Z-768) |
WOS研究方向 | Dermatology ; Pharmacology & Pharmacy |
WOS类目 | Dermatology ; Pharmacology & Pharmacy |
WOS记录号 | WOS:000390979800002 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/6662 |
专题 | 中国科学院西北高原生物研究所 |
作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xinning Lu, Xining 810008, Qinghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Fujian Med Univ, Affiliated Hosp 1, 20 Chazhong, Fuzhou 350004, Fujian, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Wenna,Xu, Heng,Luan, Guangxiang,et al. In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.[J]. SKIN PHARMACOLOGY AND PHYSIOLOGY,2016,29(5):243-249. |
APA | Zhou, Wenna,Xu, Heng,Luan, Guangxiang,Wang, HongLun,Wang, Xiaoyan,&Ji, Mingkai.(2016).In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom..SKIN PHARMACOLOGY AND PHYSIOLOGY,29(5),243-249. |
MLA | Zhou, Wenna,et al."In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.".SKIN PHARMACOLOGY AND PHYSIOLOGY 29.5(2016):243-249. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论