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In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.
Zhou, Wenna1,2; Xu, Heng1,2; Luan, Guangxiang1,2; Wang, HongLun1; Wang, Xiaoyan1; Ji, Mingkai3
2016
发表期刊SKIN PHARMACOLOGY AND PHYSIOLOGY
卷号29期号:5页码:243-249
文章类型Article
摘要Aim: The objective of this study was to evaluate the effects of seed oil of Caragana korshinskii Kom. against Trichophyton mentagrophytes on an in vivo guinea pig model of dermatophytosis. Methods: The skin of albino guinea pigs was infected with T. mentagrophytes, and the animals were divided into five groups: negative control (NC group), positive control (PC group), vehicle control, CK50% group (received topical 50% seed oil of C korshinskii), and CK100% group (received topical 100% seed oil of C korshinskii). Evaluation of clinical efficacy was performed 72 h after the completion of a 10-day treatment regimen. Skin biopsy samples were processed for histopathological examination. Results: The infected untreated control guinea pigs showed patches of hair loss and ulcerated or scaly skin. Lower clinical scores indicate improved efficacy compared with NC. The lesion scores significantly declined in the CK50%, CK100%, and PC groups in comparison with the NC group. The CK50% group (45.31%) and the CK100% group (75%) showed clinical efficacy compared with the PC group (78.13%). In addition, no fungal elements, inflammation, or tissue destruction was observed in any of the PAS-stained sections of the infected skin in the groups treated with CK100% or 1% terbinafine. Conclusion: Seed oil of C. korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis. (C) 2016 S. Karger AG, Basel
关键词Caragana Korshinskii Kom. Trichophyton Mentagrophytes Guinea Pig Model Antifungal Agent Histopathology
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1159/000448739
关键词[WOS]MICRODILUTION METHOD M38-A ; ANTIFUNGAL DRUGS ; DERMATOPHYTOSIS ; MENTAGROPHYTES ; SUSCEPTIBILITY ; RUBRUM ; MODEL ; TRANSFERRIN ; QUINCKEANUM ; EFFICACY
收录类别SCI
语种英语
项目资助者Key Program of 'The Dawn of West China' Talent Foundation of the Chinese Academy of Sciences ; National Natural Science Foundation of China(31470426 ; Qinghai Provincial Natural Science Foundation(2015-ZJ-728 ; Youth Innovation Promotion Association, Chinese Academy of Sciences(2013277) ; 31300292) ; 2015-SF-121 ; 2014-Z-768)
WOS研究方向Dermatology ; Pharmacology & Pharmacy
WOS类目Dermatology ; Pharmacology & Pharmacy
WOS记录号WOS:000390979800002
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/6662
专题中国科学院西北高原生物研究所
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xinning Lu, Xining 810008, Qinghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Fujian Med Univ, Affiliated Hosp 1, 20 Chazhong, Fuzhou 350004, Fujian, Peoples R China
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Zhou, Wenna,Xu, Heng,Luan, Guangxiang,et al. In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.[J]. SKIN PHARMACOLOGY AND PHYSIOLOGY,2016,29(5):243-249.
APA Zhou, Wenna,Xu, Heng,Luan, Guangxiang,Wang, HongLun,Wang, Xiaoyan,&Ji, Mingkai.(2016).In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom..SKIN PHARMACOLOGY AND PHYSIOLOGY,29(5),243-249.
MLA Zhou, Wenna,et al."In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caragana korshinskii Kom.".SKIN PHARMACOLOGY AND PHYSIOLOGY 29.5(2016):243-249.
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