Fe3O4 Nanoparticles with Ursolic Methyl Ester Induce Apoptosis of Multidrug-Resistant Leukemia KA Cell: In Vitro Evaluation

doi:10.1166/jnn.2016.11365

NWIPB OpenIR

	Fe3O4 Nanoparticles with Ursolic Methyl Ester Induce Apoptosis of Multidrug-Resistant Leukemia KA Cell: In Vitro Evaluation
	Yue, Huilan 3; Zhu, Gangyi 4; Liu, Xiaohang 1; Li, Congyang 1; Zhou, Tingting 1; Tao, Yanduo 3; Kang, Yanjun 5; Sun, Jiacheng 1; Tang, Yin 1; Liu, Bin 7; Zeng, Xin 2,6; Zhang, Gen 1,2
	2016-07-01
发表期刊	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号	16 期号:7 页码:7140-7144
文章类型	Article
摘要	Ferrous ferric oxide (Fe3O4) nanoparticles had captured immense attention in biomedical research because of their potential in functioning as an efficient drug delivery vector. In this study, our research investigated the synergistic effect of Fe3O4 with the anti-cancer drug ursolic methyl ester on the induction of apoptosis using drug-resistant human leukemia KA cells. Apoptotic staining, DNA fragmentation, and flow cytometry analysis demonstrated that compared with Fe3O4 or ursolic methyl ester seperated, the apoptosis rate increased sharply by the treatment of Fe3O4 together with ursolic methyl ester on KA cells. These results proved that the nanocomposites readily overcame the barrier of drug-resistance and provoked cell apoptosis in vitro by facilitating the interaction between ursolic methyl ester and KA cells. As is known to all, it is an inevitable tendency that new effective therapies will take the place of conventional chemotherapy and radiotherapy suffering from significant disadvantages. According to this article, we will find that Fe3O4 combined with ursolic methyl ester is possible alternative for some cancer treatments. This nanocomposite raises the possibility of modulating apoptosis in cancer cells, and of inhibiting tumor growth.
关键词	Nanoparticles Apoptosis Ursolic Methyl Ester Drug-resistance Anti-cancer
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1166/jnn.2016.11365
关键词[WOS]	MAGNETIC NANOPARTICLES ; BIOMEDICAL APPLICATIONS ; CANCER ; NANOCOMPOSITES ; ANTITUMOR ; DELIVERY ; PATHWAY ; SURFACE ; SYSTEM ; VIVO
收录类别	SCI
语种	英语
项目资助者	NSFC(31201003 ; 863 project of China(2012AA022703) ; State Key Laboratory of Bioelectronics of Southeast University(2012F12 ; science and technology innovation supporting fund(JX10131801149 ; Natural Science Foundation of Jiangsu Province(BK20130892 ; Advanced technology research and development program of Qinghai Province(2014-GX-220) ; 81301305 ; 2012F13 ; JX10131801147 ; BK20140900 ; 61401217) ; 2014F10) ; JX10131801154) ; 13KJB320013 ; SBK201342972 ; 13KJB310008)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000387100400075
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6669
专题	中国科学院西北高原生物研究所
作者单位	1.Nanjing Med Univ, Dept Cell Biol, Nanjing 210029, Jiangsu, Peoples R China 2.Southeast Univ, Dept Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China 3.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Tibetan Med Res, Xining 810001, Peoples R China 4.Nanjing Univ Posts & Telecommun, Grunberg Res Ctr, Nanjing 210003, Jiangsu, Peoples R China 5.Jiangnan Univ, Sch Med, Wuxi 214122, Jiangsu, Peoples R China 6.Nanjing Matern & Child Hlth Care Hosp, Maternal & Child Hlth Inst, Nanjing 210029, Jiangsu, Peoples R China 7.Nanjing Med Univ, Dept Biomed Engn, Nanjing 210029, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Yue, Huilan,Zhu, Gangyi,Liu, Xiaohang,et al. Fe3O4 Nanoparticles with Ursolic Methyl Ester Induce Apoptosis of Multidrug-Resistant Leukemia KA Cell: In Vitro Evaluation[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(7):7140-7144.
APA	Yue, Huilan.,Zhu, Gangyi.,Liu, Xiaohang.,Li, Congyang.,Zhou, Tingting.,...&Zhang, Gen.(2016).Fe3O4 Nanoparticles with Ursolic Methyl Ester Induce Apoptosis of Multidrug-Resistant Leukemia KA Cell: In Vitro Evaluation.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(7),7140-7144.
MLA	Yue, Huilan,et al."Fe3O4 Nanoparticles with Ursolic Methyl Ester Induce Apoptosis of Multidrug-Resistant Leukemia KA Cell: In Vitro Evaluation".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.7(2016):7140-7144.