Triterpenoids of Chrysosplenium carnosum

doi:10.1016/j.fitote.2013.01.006

NWIPB OpenIR

	Triterpenoids of Chrysosplenium carnosum
	Lu, Meng-ya 1; Liao, Zhi-xin 1; Ji, Lan-ju 2; Sun, Hong-fa 2
	2013-03-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	85 页码:119-124
文章类型	Article
摘要	A phytochemical study of the ethanolic extract of Chrysosplenium carnosum Hook. f. et Thoms. led to the isolation of two new oleanane-type triterpenoids, 6 beta-hydroxy-3-oxoolean-12-en-27-oic acid (1) and 3 beta, 21 alpha-dihydroxyolean-12-en-27-oic acid (2), along with fourteen known compounds (3-16), all of which were isolated from this plant for the first time. The structures of these compounds were established on the basis of spectroscopic methods. Compounds 1-4 were evaluated for their in vitro anti-tumor activities on B16F10, SP2/0 and Hep-G2 cells lines. Compounds 1,3 and 4 exhibited strong inhibitory activity against B16F10 and SP2/0 cells' growth, compared with moderate cytotoxic activity against Hep-G2 cells. However, compound 2 showed to be inactive against these tumor cells. (C) 2013 Elsevier B.V. All rights reserved.
关键词	Chrysosplenium Carnosum Hook. F. Et Thoms. Triterpenoid Anti-tumor Activity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.fitote.2013.01.006
关键词[WOS]	ACERIPHYLLUM-ROSSII ; ASTILBE-CHINENSIS ; FLAVONOIDS ; CYTOTOXICITY ; GRAYANUM ; CELLS
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(30770233)
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000317172000018
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6681
专题	中国科学院西北高原生物研究所
通讯作者	Liao, Zhi-xin
作者单位	1.Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northweast Inst Plateau Biol, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Lu, Meng-ya,Liao, Zhi-xin,Ji, Lan-ju,et al. Triterpenoids of Chrysosplenium carnosum[J]. FITOTERAPIA,2013,85:119-124.
APA	Lu, Meng-ya,Liao, Zhi-xin,Ji, Lan-ju,&Sun, Hong-fa.(2013).Triterpenoids of Chrysosplenium carnosum.FITOTERAPIA,85,119-124.
MLA	Lu, Meng-ya,et al."Triterpenoids of Chrysosplenium carnosum".FITOTERAPIA 85(2013):119-124.