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First separation of four aromatic acids and two analogues with similar structures and polarities from Clematis akebioides by high-speed counter-current chromatography
Gong, Chengcheng1; Chen, Tao2; Chen, Huifeng1; Zhang, Shanshan1; Wang, Xinzhu1; Wang, Weiqing3; Sun, Jing2; Li, Yulin2; Liao, Zhixin1
2016-12-01
Source PublicationJOURNAL OF SEPARATION SCIENCE
Volume39Issue:23Pages:4660-4666
SubtypeArticle
AbstractIn this paper, we report an efficient method by high-speed counter-current chromatography for the first separation of four aromatic acids and two analogs with similar structures and polarities from Clematis akebioides. First, the ethyl acetate extract was treated by silica gel column chromatography to enrich the target compounds. And then the fraction with target compounds were purified by high-speed counter-counter chromatography using a two-phase solvent system consisting of chloroform/acetonitrile/water (10:6:4, v/v). The results showed high-speed counter-current chromatography could be a powerful technology for the separation of compounds with similar structures and polarities. Besides, it was found acetonitrile could be a good methanol substitute when a chloroform/methanol/water system could not provide a good separation factor. This study provides a reference for the separation of compounds from Clematis akebioides.
KeywordAromatic Acids Clematis Akebioides High-speed Counter-counter Chromatography
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/jssc.201600805
WOS KeywordPREPARATIVE SEPARATION ; CHEMICAL-CONSTITUENTS ; RHEUM-TANGUTICUM ; PURIFICATION ; EXTRACTION ; FLAVONOIDS ; HPLC
Indexed BySCI
Language英语
Funding Organizationpriority academic program development of Jiangsu higher Education Institutions(1107047002) ; National Natural Science Foundation of China(81403051) ; Instrument Function Development Project of CAS(2017g107)
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000393030100023
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/6781
Collection中国科学院西北高原生物研究所
Affiliation1.Southeast Univ, Sch Chem & Chem Engn, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Peoples R China
3.Qinghai Prov Prod Qual Supervis & Inspect Ctr, Xining, Peoples R China
Recommended Citation
GB/T 7714
Gong, Chengcheng,Chen, Tao,Chen, Huifeng,et al. First separation of four aromatic acids and two analogues with similar structures and polarities from Clematis akebioides by high-speed counter-current chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(23):4660-4666.
APA Gong, Chengcheng.,Chen, Tao.,Chen, Huifeng.,Zhang, Shanshan.,Wang, Xinzhu.,...&Liao, Zhixin.(2016).First separation of four aromatic acids and two analogues with similar structures and polarities from Clematis akebioides by high-speed counter-current chromatography.JOURNAL OF SEPARATION SCIENCE,39(23),4660-4666.
MLA Gong, Chengcheng,et al."First separation of four aromatic acids and two analogues with similar structures and polarities from Clematis akebioides by high-speed counter-current chromatography".JOURNAL OF SEPARATION SCIENCE 39.23(2016):4660-4666.
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