Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection

doi:10.1038/srep45313

NWIPB OpenIR

	Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection
	Kang, Yanjun 1; Wu, Yi-Zhou 2; Hu, Xianyun 3; Xu, Xueqin 2; Sun, Jie 4; Geng, Rong 2; Huang, Tongxing 2; Liu, Xiaohang 2; Ma, Yichen 2; Chen, Ying 2; Wan, Quan 2; Qi, Xiaobang 2; Zhang, Gen 2; Zhao, Xiaohui 5; Zeng, Xin 6
	2017-03-27
发表期刊	SCIENTIFIC REPORTS
卷号	7
文章类型	Article
摘要	Because they generate excellent images, nanoparticles (NPs), especially biosynthesized NPs, provide a new solution for tumor imaging. In this research, we unveil a novel type of biosynthesized NPs featuring multicolor fluorescence. These NPs exhibit little cytotoxicity to cells. The explored NPs, designated ZnZFP- GST NPs (Zinc NPs in abbreviation), are generated from leukemia cells treated with a Zn2+ solution, while zinc-finger protein and glutathione S-transferase (GST) were also identified in the Zinc NPs. Under near-UV illumination, the Zinc NPs simultaneously emit green, yellow, and red fluorescence. In addition, the intensity of the fluorescence increases with the existence of sulfides. Besides, the NPs are encapsulated by microvesicles (MVs) shed from the plasma membrane. As observed in wholebody research of nude mice, the NP-MVs migrate via blood circulation and are distinguished by their fluorescent signals. Furthermore, the folic acid (FA) & AVR2 (human VEGF antibody)-coated NP-MVs are exploited to target the tumor location, and the feasibility of this approach has been confirmed empirically. The Zinc NPs shed light on an alternative solution to tumor detection.
WOS标题词	Science & Technology
DOI	10.1038/srep45313
关键词[WOS]	CDSE QUANTUM DOTS ; IN-VIVO ; LIVE CELLS ; CANCER ; GREEN ; MICROVESICLES ; NANOCRYSTALS ; DIAGNOSTICS ; CADMIUM ; PET/CT
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foudation of China(81370679 ; Jiangsu provincial key research and development program(BE2016620) ; Jiangsu planned projects for postdoctoral research funds(1601010C) ; medical science and technology development foundation, Nanjing Department of Health(JQX15010) ; 81301305 ; 21545006)
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000397539800001
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/6796
专题	中国科学院西北高原生物研究所
作者单位	1.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China 2.Nanjing Med Univ, Sch Basic Med Sci, Dept Cell Biol, Nanjing 210029, Peoples R China 3.Qiannan Med Coll National, Dept Biochem, Duyun 558000, Peoples R China 4.Nanjing Med Univ, Ctr Hygien Anal & Detect, Sch Publ Hlth, Nanjing 211166, Peoples R China 5.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Peoples R China 6.Nanjing Med Univ, Obstet & Gynecol Hosp Affiliated, Nanjing Matern & Child Hlth Med Inst, Nanjing 210004, Peoples R China
推荐引用方式 GB/T 7714	Kang, Yanjun,Wu, Yi-Zhou,Hu, Xianyun,et al. Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection[J]. SCIENTIFIC REPORTS,2017,7.
APA	Kang, Yanjun.,Wu, Yi-Zhou.,Hu, Xianyun.,Xu, Xueqin.,Sun, Jie.,...&Zeng, Xin.(2017).Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection.SCIENTIFIC REPORTS,7.
MLA	Kang, Yanjun,et al."Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection".SCIENTIFIC REPORTS 7(2017).