NWIPB OpenIR
Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection
Kang, Yanjun1; Wu, Yi-Zhou2; Hu, Xianyun3; Xu, Xueqin2; Sun, Jie4; Geng, Rong2; Huang, Tongxing2; Liu, Xiaohang2; Ma, Yichen2; Chen, Ying2; Wan, Quan2; Qi, Xiaobang2; Zhang, Gen2; Zhao, Xiaohui5; Zeng, Xin6
2017-03-27
Source PublicationSCIENTIFIC REPORTS
Volume7
SubtypeArticle
AbstractBecause they generate excellent images, nanoparticles (NPs), especially biosynthesized NPs, provide a new solution for tumor imaging. In this research, we unveil a novel type of biosynthesized NPs featuring multicolor fluorescence. These NPs exhibit little cytotoxicity to cells. The explored NPs, designated ZnZFP- GST NPs (Zinc NPs in abbreviation), are generated from leukemia cells treated with a Zn2+ solution, while zinc-finger protein and glutathione S-transferase (GST) were also identified in the Zinc NPs. Under near-UV illumination, the Zinc NPs simultaneously emit green, yellow, and red fluorescence. In addition, the intensity of the fluorescence increases with the existence of sulfides. Besides, the NPs are encapsulated by microvesicles (MVs) shed from the plasma membrane. As observed in wholebody research of nude mice, the NP-MVs migrate via blood circulation and are distinguished by their fluorescent signals. Furthermore, the folic acid (FA) & AVR2 (human VEGF antibody)-coated NP-MVs are exploited to target the tumor location, and the feasibility of this approach has been confirmed empirically. The Zinc NPs shed light on an alternative solution to tumor detection.
WOS HeadingsScience & Technology
DOI10.1038/srep45313
WOS KeywordCDSE QUANTUM DOTS ; IN-VIVO ; LIVE CELLS ; CANCER ; GREEN ; MICROVESICLES ; NANOCRYSTALS ; DIAGNOSTICS ; CADMIUM ; PET/CT
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foudation of China(81370679 ; Jiangsu provincial key research and development program(BE2016620) ; Jiangsu planned projects for postdoctoral research funds(1601010C) ; medical science and technology development foundation, Nanjing Department of Health(JQX15010) ; 81301305 ; 21545006)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000397539800001
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/6796
Collection中国科学院西北高原生物研究所
Affiliation1.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China
2.Nanjing Med Univ, Sch Basic Med Sci, Dept Cell Biol, Nanjing 210029, Peoples R China
3.Qiannan Med Coll National, Dept Biochem, Duyun 558000, Peoples R China
4.Nanjing Med Univ, Ctr Hygien Anal & Detect, Sch Publ Hlth, Nanjing 211166, Peoples R China
5.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Peoples R China
6.Nanjing Med Univ, Obstet & Gynecol Hosp Affiliated, Nanjing Matern & Child Hlth Med Inst, Nanjing 210004, Peoples R China
Recommended Citation
GB/T 7714
Kang, Yanjun,Wu, Yi-Zhou,Hu, Xianyun,et al. Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection[J]. SCIENTIFIC REPORTS,2017,7.
APA Kang, Yanjun.,Wu, Yi-Zhou.,Hu, Xianyun.,Xu, Xueqin.,Sun, Jie.,...&Zeng, Xin.(2017).Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection.SCIENTIFIC REPORTS,7.
MLA Kang, Yanjun,et al."Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection".SCIENTIFIC REPORTS 7(2017).
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