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Heat shock response and mammal adaptation to high elevation (hypoxia)
Wang Xiaolin; Xu Cunshuan; Wang Xiujie; Wang Dongjie; Wang Qingshang; Zhang Baochen
2006-10-01
发表期刊SCIENCE IN CHINA SERIES C-LIFE SCIENCES
卷号49期号:5页码:500-512
文章类型Article
摘要The mammal's high elevation (hypoxia) adaptation was studied by using the immunological and the molecular biological methods to understand the significance of Hsp (hypoxia) adaptation in the organic high elevation, through the mammal heat shock response. (1) From high elevation to low elevation (natural hypoxia): Western blot and conventional RT-PCR and real-time fluorescence quota PCR were adopted. Expression difference of heat shock protein of 70 (Hsp70) and natural expression of brain tissue of Hsp70 gene was determined in the cardiac muscle tissue among the different elevation mammals (yak). (2)From low elevation to high elevation (hypoxia induction): The mammals (domestic rabbits) from the low elevation were sent directly to the areas with different high elevations like 2300,3300 and 5000 m above sea level to be raised for a period of 3 weeks before being slaughtered and the genetic inductive expression of the brain tissue of Hsp70 was determined with RT-PCR. The result indicated that all of the mammals at different elevations possessed their heat shock response gene. Hsp70 of the high elevation mammal rose abruptly under stress and might be induced to come into being by high elevation (hypoxia). The speedy synthesis of Hsp70 in the process of heat shock response is suitable to maintain the cells' normal physiological functions under stress. The Hsp70 has its threshold value. The altitude of 5000 m above sea level is the best condition for the heat shock response, and it starts to reduce when the altitude is over 6000 m above sea level. The Hsp70 production quantity and the cell hypoxia bearing capacity have their direct ratio.
关键词Heat Shock Reaction Heat Shock Protein 70 (Hsp70) Western Blot Rt-pcr Fluorescence Quota Pcr High Elevation Hypoxia Mammal Stress
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ACCLIMATION-INDUCED VARIATION ; SNAILS GENUS TEGULA ; DROSOPHILA-MELANOGASTER ; PROTEIN-SYNTHESIS ; TRANSPOSABLE ELEMENTS ; HSP70 EXPRESSION ; STRESS-RESPONSE ; EVOLUTIONARY ; THERMOTOLERANCE ; TEMPERATURES
收录类别SCI
语种英语
WOS研究方向Life Sciences & Biomedicine - Other Topics
WOS类目Biology
WOS记录号WOS:000242641700013
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/6855
专题中国科学院西北高原生物研究所
作者单位1.Chinese Acad Sci, NW Plateau Biol Res Inst, Xining 810001, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Qinghai Univ, Affiliated Hosp, Coll Med, Xining 810001, Peoples R China
4.Henan Normal Univ, Key Lab Minist Sci & Technol China, Xinxiang 453000, Peoples R China
5.Sichuan Univ, Key Lab, China Minist Educ, Oncol Res Inst,Western Hosp, Chengdu 610041, Peoples R China
6.Guangzhou Meizheng Pharmaceut Ind, Guangzhou 510075, Peoples R China
7.Minist Hlth China, Key Lab, Guangzhou 510075, Peoples R China
8.China Trop Agr Acad Sci, Rubber Res Inst, Haikou 571737, Peoples R China
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GB/T 7714
Wang Xiaolin,Xu Cunshuan,Wang Xiujie,et al. Heat shock response and mammal adaptation to high elevation (hypoxia)[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2006,49(5):500-512.
APA Wang Xiaolin,Xu Cunshuan,Wang Xiujie,Wang Dongjie,Wang Qingshang,&Zhang Baochen.(2006).Heat shock response and mammal adaptation to high elevation (hypoxia).SCIENCE IN CHINA SERIES C-LIFE SCIENCES,49(5),500-512.
MLA Wang Xiaolin,et al."Heat shock response and mammal adaptation to high elevation (hypoxia)".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 49.5(2006):500-512.
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